公开(公告)号：US20180305390A1

公开(公告)日：2018-10-25

申请号：US15738675

申请日：2016-06-23

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Hong LIU ,  Jia LI ,  Jiang WANG ,  Jingya LI ,  Hui CHEN ,  Dan LI ,  Jian LI ,  Yibing WANG ,  Hualiang JIANG ,  Kaixian CHEN

IPC分类号： C07H19/01 ,  A61P3/08

CPC分类号： C07H19/01 ,  A61K31/35 ,  A61K31/381 ,  A61K31/427 ,  A61K31/4436 ,  A61P3/08 ,  C07D493/10

摘要： C, O-spiro aryl glycoside compounds are provided. Specifically provided are C, O-spiro aryl glycoside compounds represented by the formula (I), wherein the definitions of each variable group are described in the specification. Also provided are methods of preparing and using the C, O-spiro aryl glycoside compounds. The C, O-spiro aryl glycoside compounds can be used as SGLT2 inhibitors and for treating diseases, such as diabetes, atherosclerosis, and adiposity.