公开(公告)号：US20240262860A1

公开(公告)日：2024-08-08

申请号：US18014932

申请日：2021-07-05

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Hong LIU ,  Jiang WANG ,  Yichu LIU ,  Changyue YU ,  Yibing WANG ,  Hualiang JIANG ,  Kaixian CHEN

IPC: C07J63/00 ,  A61K31/704 ,  A61P3/10 ,  A61P31/14 ,  A61P31/16

CPC classification number: C07J63/008 ,  A61K31/704 ,  A61P3/10 ,  A61P31/14 ,  A61P31/16

Abstract: The present invention provides a pentacyclic triterpenoid glycoside compound, and a preparation method therefor and a use thereof. Specifically, the present invention provides a compound as shown in formula I. The definition of each group is described in the description. The compound can be used for preparing a medicament for treating metabolic diseases such as diabetes and viral diseases caused by influenza virus, coronavirus and the like.

公开(公告)号：US20180305390A1

公开(公告)日：2018-10-25

申请号：US15738675

申请日：2016-06-23

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Hong LIU ,  Jia LI ,  Jiang WANG ,  Jingya LI ,  Hui CHEN ,  Dan LI ,  Jian LI ,  Yibing WANG ,  Hualiang JIANG ,  Kaixian CHEN

IPC: C07H19/01 ,  A61P3/08

CPC classification number: C07H19/01 ,  A61K31/35 ,  A61K31/381 ,  A61K31/427 ,  A61K31/4436 ,  A61P3/08 ,  C07D493/10

Abstract: C, O-spiro aryl glycoside compounds are provided. Specifically provided are C, O-spiro aryl glycoside compounds represented by the formula (I), wherein the definitions of each variable group are described in the specification. Also provided are methods of preparing and using the C, O-spiro aryl glycoside compounds. The C, O-spiro aryl glycoside compounds can be used as SGLT2 inhibitors and for treating diseases, such as diabetes, atherosclerosis, and adiposity.