公开(公告)号：US20190039989A1

公开(公告)日：2019-02-07

申请号：US16075528

申请日：2017-02-20

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Fajun NAN ,  Jia LI ,  Jingya LI ,  Mei ZHANG ,  Zhifu XIE ,  Jingtao WANG ,  Dongdong GUO

IPC: C07C61/35 ,  C07C57/13 ,  C07C57/26

CPC classification number: C07C61/35 ,  A61K31/194 ,  C07C55/28 ,  C07C57/13 ,  C07C57/26 ,  C07C57/42 ,  C07C61/16 ,  C07C61/20 ,  C07C61/22 ,  C07C2601/08 ,  C07C2601/16 ,  Y02P20/55

Abstract: The present invention relates to a class of fatty acid compounds, a preparation method thereof and use thereof. The fatty acid compounds have the structure of the formula I, which has the ability to activate APMK and inhibit the glucose output in mouse primary hepatocytes. The fatty acid compounds can be used in preparing a medicament for the treatment of obesity or diabetes.