公开(公告)号：US20190039989A1

公开(公告)日：2019-02-07

申请号：US16075528

申请日：2017-02-20

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Fajun NAN ,  Jia LI ,  Jingya LI ,  Mei ZHANG ,  Zhifu XIE ,  Jingtao WANG ,  Dongdong GUO

IPC分类号： C07C61/35 ,  C07C57/13 ,  C07C57/26

CPC分类号： C07C61/35 ,  A61K31/194 ,  C07C55/28 ,  C07C57/13 ,  C07C57/26 ,  C07C57/42 ,  C07C61/16 ,  C07C61/20 ,  C07C61/22 ,  C07C2601/08 ,  C07C2601/16 ,  Y02P20/55

摘要： The present invention relates to a class of fatty acid compounds, a preparation method thereof and use thereof. The fatty acid compounds have the structure of the formula I, which has the ability to activate APMK and inhibit the glucose output in mouse primary hepatocytes. The fatty acid compounds can be used in preparing a medicament for the treatment of obesity or diabetes.

公开(公告)号：US20170247371A1

公开(公告)日：2017-08-31

申请号：US15326310

申请日：2015-07-14

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Fajun NAN ,  Jia LI ,  Jingya LI ,  Mei ZHANG ,  Dakai CHEN ,  Lina ZHANG ,  Runtao ZHANG ,  Zhifu XIE

IPC分类号： C07D471/04 ,  C12N9/12 ,  C07D211/78

CPC分类号： C07D471/04 ,  A61K31/437 ,  C07D211/78 ,  C12N9/12 ,  C12Y207/11031

摘要： Provided are a class of pyrazolone compounds and a use thereof. In particular, a compound represented by formula I is provided, wherein the definition of each variable group is as described in the description. The compounds of formula (I) have a direct AMPK-activating activity and can significantly promote the phosphorylation of AMPK and ACC of L6 myocytes and HepG2 cells in a dose-dependent manner.