公开(公告)号：US20130281426A1

公开(公告)日：2013-10-24

申请号：US13921009

申请日：2013-06-18

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Youhong HU ,  Liguang Lou ,  Shijun Lin ,  Hongbing Zhao ,  Zhende Liu ,  Yongping Xu ,  Bo Chao

IPC: C07D237/14 ,  C07D413/10 ,  C07D295/155 ,  C07D401/10 ,  C07D403/10

CPC classification number: C07D237/14 ,  A61K31/50 ,  A61K31/501 ,  A61K31/5377 ,  C07D295/155 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

Abstract: The present invention relates to a class of pyridazinones of formula I, which comprises 6-[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one as a mother nucleus, the preparation method thereof and the use thereof in manufacturing medicaments against tumors, especially liver cancer.

Abstract translation: 本发明涉及一类式I的哒嗪酮，其包含作为母核的6- [3-（三氟甲基）苯基]哒嗪-3（2H） - 酮，其制备方法及其在制备药物中的用途 肿瘤，特别是肝癌。

公开(公告)号：US09212146B2

公开(公告)日：2015-12-15

申请号：US13921009

申请日：2013-06-18

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Youhong Hu ,  Liguang Lou ,  Shijun Lin ,  Hongbing Zhao ,  Zhende Liu ,  Yongping Xu ,  Bo Chao

IPC: C07D237/14 ,  C07D401/10 ,  C07D403/10 ,  C07D295/155 ,  C07D413/10 ,  A61K31/501 ,  A61K31/50 ,  A61K31/5377

CPC classification number: C07D237/14 ,  A61K31/50 ,  A61K31/501 ,  A61K31/5377 ,  C07D295/155 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

Abstract: The present invention relates to a class of pyridazinones of formula I, which comprises 6-[3-(trifluoromethyl)phenyl]pyridazin-3(2H)-one as a mother nucleus, the preparation method thereof and the use thereof in manufacturing medicaments against tumors, especially liver cancer.

Abstract translation: 本发明涉及一类式I的哒嗪酮，其包含作为母核的6- [3-（三氟甲基）苯基]哒嗪-3（2H） - 酮，其制备方法及其在制备药物中的用途 肿瘤，特别是肝癌。