公开(公告)号：US20170247371A1

公开(公告)日：2017-08-31

申请号：US15326310

申请日：2015-07-14

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Fajun NAN ,  Jia LI ,  Jingya LI ,  Mei ZHANG ,  Dakai CHEN ,  Lina ZHANG ,  Runtao ZHANG ,  Zhifu XIE

IPC分类号： C07D471/04 ,  C12N9/12 ,  C07D211/78

CPC分类号： C07D471/04 ,  A61K31/437 ,  C07D211/78 ,  C12N9/12 ,  C12Y207/11031

摘要： Provided are a class of pyrazolone compounds and a use thereof. In particular, a compound represented by formula I is provided, wherein the definition of each variable group is as described in the description. The compounds of formula (I) have a direct AMPK-activating activity and can significantly promote the phosphorylation of AMPK and ACC of L6 myocytes and HepG2 cells in a dose-dependent manner.