专利检索 ap:("SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES" OR "TOPHARMAN SHANGHAI CO., LTD." OR "LIAN V NANTONG CO., LTD.") AND inv:"Hongjian QIN" 第 1 页

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发明申请
FUSED RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 有权

公开(公告)号：US20220227773A1

公开(公告)日：2022-07-21

申请号：US17615300

申请日：2020-05-29

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , TOPHARMAN SHANGHAI CO., LTD. , LIAN V NANTONG CO., LTD.

发明人： Jingshan SHEN , Yang HE , Chunhui WU , Feipu YANG , Zhen WANG , Junchi ZHANG , Fuqiang ZHU , Hongjian QIN

IPC分类号： C07D487/04 , C07D409/04 , C07D405/04 , C07D209/52

摘要： The present invention relates to a fused ring compound represented by general formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition and use thereof. The compound provided in the present invention is useful for treating, preventing and/or controlling various nervous system disorders. The compound provided in the present invention modulates one or more monoamine transporters, inhibits the reuptake of endogenous monoamines such as dopamine, 5-hydroxytryptamine, and norepinephrine (e.g., from the synaptic cleft), and/or modulates the 5-HT3 receptor.