公开(公告)号：US20220227773A1

公开(公告)日：2022-07-21

申请号：US17615300

申请日：2020-05-29

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  TOPHARMAN SHANGHAI CO., LTD. ,  LIAN V NANTONG CO., LTD.

发明人： Jingshan SHEN ,  Yang HE ,  Chunhui WU ,  Feipu YANG ,  Zhen WANG ,  Junchi ZHANG ,  Fuqiang ZHU ,  Hongjian QIN

IPC分类号： C07D487/04 ,  C07D409/04 ,  C07D405/04 ,  C07D209/52

摘要： The present invention relates to a fused ring compound represented by general formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition and use thereof. The compound provided in the present invention is useful for treating, preventing and/or controlling various nervous system disorders. The compound provided in the present invention modulates one or more monoamine transporters, inhibits the reuptake of endogenous monoamines such as dopamine, 5-hydroxytryptamine, and norepinephrine (e.g., from the synaptic cleft), and/or modulates the 5-HT3 receptor.

公开(公告)号：US20170298080A1

公开(公告)日：2017-10-19

申请号：US15509796

申请日：2015-09-11

申请人： SUZHOU VIGONVITA LIFE SCIENCES CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  TOPHARMAN SHANGHAI CO., LTD.

发明人： Jingshan SHEN ,  Zheng LIU ,  Zhen WANG ,  Guanghui TIAN ,  Jianfeng LI ,  Xiaojun YANG

IPC分类号： C07D495/04 ,  C07D275/04 ,  C07D261/20 ,  C07D333/20 ,  C07D231/56

CPC分类号： C07D495/04 ,  A61K31/33 ,  A61K31/381 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  C07D209/14 ,  C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  C07D307/77 ,  C07D333/20 ,  C07D333/46

摘要： Disclosed are aminosulfonyl-based compounds represented by the general formula I or tautomers, enantiomers, racemates or pharmaceutically acceptable salts thereof, a method for preparing the same, pharmaceutical compositions and uses thereof. The compounds can be used to treat epilepsy, convulsions, obesity and the like.

公开(公告)号：US20230312584A1

公开(公告)日：2023-10-05

申请号：US18033673

申请日：2021-10-21

申请人： VIGONVITA LIFE SCIENCES CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  WUHAN INSTITUTE OF VIROLOGY, CHINESE ACADEMY OF SCIENCES

发明人： Jingshan SHEN ,  Yuanchao XIE ,  Leike ZHANG ,  Gengfu XIAO ,  Zhen WANG ,  Hualiang JIANG ,  Huaqiang XU ,  Tianwen HU ,  Guanghui TIAN

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  C07B2200/13

摘要： A salt of nucleoside analog, and crystal form, pharmaceutical composition and use thereof. The salt of nucleoside analog has a structure shown in formula I, wherein X is hydrogen or deuterium; Y is an acid, n is 0.5 to 2, or n is 1. When X is hydrogen or deuterium, Y is hydrogen bromide, and n is 1, the salt of the nucleoside analog exists in the form of a crystal with crystal form I or crystal form A or exists in an amorphous form.

公开(公告)号：US20170158680A1

公开(公告)日：2017-06-08

申请号：US15124264

申请日：2015-03-09

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  SUZHOU VIGONVITA LIFE SCIENCES CO., LTD. ,  TOPHARMAN SHANDONG CO., LTD.

发明人： Hualiang JIANG ,  Zhen WANG ,  Jianfeng LI ,  Rongxia ZHANG ,  Yang HE ,  Yongjian LIU ,  Minghao BI ,  Zheng LIU ,  Guanghui TIAN ,  Weiming CHEN ,  Feipu YANG ,  Chunhui WU ,  Yu WANG ,  Xiangrui JIANG ,  Jingjing YIN ,  Guan WANG ,  Jingshan SHEN

IPC分类号： C07D409/12 ,  C07D495/04 ,  C07D471/04

CPC分类号： C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D519/00

摘要： The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.

公开(公告)号：US20200255421A1

公开(公告)日：2020-08-13

申请号：US16639394

申请日：2018-08-14

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMYOF SCIENCES ,  TOPHARMAN SHANGHAI CO., LTD.

发明人： Yang HE ,  Xiangrui JIANG ,  Jianfeng LI ,  Yu WANG ,  Zhen WANG ,  Weiming CHEN ,  Fuqiang ZHU ,  Chunhui WU ,  Rongxia ZHANG ,  Jingshan SHEN ,  Hualiang JIANG

IPC分类号： C07D455/03 ,  A61P25/20 ,  C07D498/14

摘要： The present invention provides a tetrahydroprotoberberine compound represented by the formula (I), enantiomers, diastereomers, racemates and mixtures thereof, and pharmaceutically acceptable salts, crystalline hydrates and solvates thereof. The invention also provides a method for preparing the compound and the use thereof in the preparation of a medicament for preventing and/or treating central nervous system diseases.