公开(公告)号：US20230372582A1

公开(公告)日：2023-11-23

申请号：US18363760

申请日：2023-08-02

申请人： SHANGHAI LINGEL MEDICAL TECHNOLOGY CO., LTD.

发明人： Yiqing ZHANG ,  Yu SUN

IPC分类号： A61L26/00 ,  A61L31/14 ,  A61L24/00 ,  A61L24/04 ,  A61L31/04 ,  C08G65/333 ,  C08G69/50 ,  C08G63/91

CPC分类号： A61L26/008 ,  A61L31/145 ,  A61L24/0031 ,  A61L24/043 ,  A61L26/0052 ,  A61L31/041 ,  C08G65/33396 ,  C08G69/50 ,  C08G63/912 ,  A61L2400/04

摘要： This invention provides the preparation and applications of a degradable dual-component hydrogel. The hydrogel is prepared by mixing component A, component B and solvent; Component A is an o-phthalaldehyde modified degradable polymer; Component B is a water-soluble molecule, a water-soluble synthetic polymer, or a polysaccharide that contains one or more types of the groups selected from primary amine, hydrazine, hydrazide, hydroxylamine and sulfhydryl, with the number of groups not less than 2. This invention achieves the regulation for hydrogel degradability by introducing degradable structures into the polymer skeleton of component A, and obtains hydrogels with rapid degradation. This invention thus solve the dilemma of materials—confronting either the problems of undegradable poly (ethylene glycol) skeleton or the potential risks of the degradable bioproducts introduced—used for preparing the dual-component hydrogel.