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1.发明申请公开(公告)号：US20200270230A1
公开(公告)日：2020-08-27
申请号：US16645777
申请日：2018-09-17
发明人： Xin Xu , Zhen Zhang , Yunfei Li , Liming Zhang , Fengying Guo , Qingyun Jiang , Dongsheng Li , Linli Zhang , Jinqian Song , Lei Liu , Qiang Liu , Jing Su , Yijin Wang , Jian Ge
IPC分类号： C07D405/04 , C07D405/14 , C07D495/04 , C07D417/14
摘要： Disclosed are a class of μ-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The μ-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.
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2.发明授权公开(公告)号：US11072601B2
公开(公告)日：2021-07-27
申请号：US16645777
申请日：2018-09-17
发明人： Xin Xu , Zhen Zhang , Yunfei Li , Liming Zhang , Fengying Guo , Qingyun Jiang , Dongsheng Li , Linli Zhang , Jinqian Song , Lei Liu , Qiang Liu , Jing Su , Yijin Wang , Jian Ge
IPC分类号： C07D405/04 , C07D405/14 , C07D495/04 , C07D417/14
摘要： Disclosed are a class of μ-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The μ-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.
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