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公开(公告)号：US20190169147A1
公开(公告)日：2019-06-06
申请号：US16086615
申请日：2017-03-28
发明人： Yunfei LI , Xiaoer XIA , Xin XU , Zhen ZHANG , Lei LIU , Xiaojuan ZHANG , Liming ZHANG , Dongsheng LI , Yijin WANG , Jian GE
IPC分类号： C07D295/096
摘要： The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present application provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present application prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.
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2.发明申请公开(公告)号：US20200270230A1
公开(公告)日：2020-08-27
申请号：US16645777
申请日：2018-09-17
发明人： Xin Xu , Zhen Zhang , Yunfei Li , Liming Zhang , Fengying Guo , Qingyun Jiang , Dongsheng Li , Linli Zhang , Jinqian Song , Lei Liu , Qiang Liu , Jing Su , Yijin Wang , Jian Ge
IPC分类号： C07D405/04 , C07D405/14 , C07D495/04 , C07D417/14
摘要： Disclosed are a class of μ-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The μ-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.
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公开(公告)号：US20230111910A1
公开(公告)日：2023-04-13
申请号：US17794390
申请日：2021-01-21
发明人： Xin XU , Jia CHEN , Liming ZHANG , Xuqin YANG , Maozhi YANG , Xiaojuan ZHANG , Yanxiao XU , Xiaobo ZHOU , Hao YU , Yuyun ZHANG , Ying WANG , Xiaoer XIA
IPC分类号： C07D519/00 , C07D401/12 , C07D417/12 , C07D513/04 , C07D471/04 , A61P35/00
摘要： Provided are a compound as a PD-L1 inhibitor, a preparation method therefor, and use thereof. Further provided is use of the compound or a pharmaceutical composition thereof in the preparation of a medicine, wherein the medicine is used for preventing and treating a PD-L1-related disease.
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公开(公告)号：US20220062249A1
公开(公告)日：2022-03-03
申请号：US17523229
申请日：2021-11-10
发明人： Jian GE , Yunfei LI , Lihong LIN , Dengxue SUN , Jiamiao WANG , Yijin WANG , Zhiyun WANG
摘要： A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals having an average particle size of 2-52 μm.
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公开(公告)号：US20220024941A1
公开(公告)日：2022-01-27
申请号：US17442331
申请日：2020-03-24
发明人： Xin XU , Jia CHEN , Zhen ZHANG , Liming ZHANG , Qimei WU , Qingyun JIANG , Fengying GUO , Yuyun ZHANG , Hao YU , Xiaojuan ZHANG , Kang SUN , Xiaobo ZHOU , Chengxu ZANG , Yijin WANG , Xiaoer XIA , Yunfei LI , Jian GE
IPC分类号： C07D491/107 , C07D471/10 , C07D405/14 , C07D495/10
摘要： Provided are a preparation method for amide compounds and use thereof in medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer homolog 2 (EZH2) of Zeste gene, and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.
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公开(公告)号：US11197850B2
公开(公告)日：2021-12-14
申请号：US16465116
申请日：2018-02-13
发明人： Jian Ge , Yunfei Li , Lihong Lin , Dengxue Sun , Jiamiao Wang , Yijin Wang , Zhiyun Wang
摘要： A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals, and the average grain size of the crystals ranges from 0.5 μm to 100 μm.
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公开(公告)号：US20230348471A1
公开(公告)日：2023-11-02
申请号：US18002133
申请日：2021-06-18
发明人： Xin Xu , Jia Chen , Guan Wang , Linli Zhang , Qingyun Jiang , Chenghao Xi , Kang Sun , Xiaojuan Zhang , Chunqiao Chen , Shuai Li , Qiang Li , Liangze Xia , Ying Wang , Xiaoer Xia
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00 , A61P19/02 , A61P11/00 , A61P37/06
CPC分类号： C07D487/04 , C07D519/00 , A61P35/00 , A61P19/02 , A61P11/00 , A61P37/06
摘要： A type of Bruton's tyrosine kinase inhibitor, a preparation method therefor, and an application thereof in the field of medicine. The Bruton's tyrosine kinase inhibitor may be used for preventing and/or treating a disease related to Bruton's tyrosine kinase mediation, such as an autoimmune disease, cancer, or an inflammatory disease. Through experimental research, the provided compound has high selectivity with respect to a Bruton's tyrosine kinase target, and can exhibit a uniquely advantageous medicinal effect in an in vivo animal experiment.
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公开(公告)号：US20220098178A1
公开(公告)日：2022-03-31
申请号：US17442899
申请日：2020-03-24
发明人： Xin XU , Jia CHEN , Zhen ZHANG , Liming ZHANG , Qimei WU , Qingyun JIANG , Fengying GUO , Yuyun ZHANG , Hao YU , Ying WANG , Kang SUN , Chengxu ZANG , Chenggang QIN , Xiaobo ZHOU , Xiaojuan ZHANG , Yijin WANG , Xiaoer XIA , Yunfei LI , Jian GE
IPC分类号： C07D405/14 , A61P35/00 , C07D405/12 , C07D487/04
摘要： The present invention relates to a preparation method for an amide compound and an application thereof in the field of medicine. Specifically, provided by the present invention is an amide small molecule compound which is an inhibitor of Zeste gene enhancer homolog 2 (EZH2) and which may be used to prevent and/or treat EZH2-mediated related diseases, comprising tumors, myeloproliferative diseases or autoimmune diseases.
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公开(公告)号：US20180250305A1
公开(公告)日：2018-09-06
申请号：US15756476
申请日：2016-09-06
发明人： Jian GE , Yunfei LI , Zhen ZHANG , Yijin WANG , Jiamiao WANG , Tao CHENG
IPC分类号： A61K31/5355 , A61K31/519 , A61K31/517 , A61K31/4418 , A61P3/06 , A61P3/10 , A61P9/10 , A61P25/28
CPC分类号： A61K31/5355 , A61K31/4418 , A61K31/517 , A61K31/519 , A61P3/06 , A61P3/10 , A61P9/10 , A61P25/28 , C07D217/24 , C07D239/91
摘要： Provided are a type of compounds that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds and the compositions can improve lipid metabolism disorders by increasing high-density lipoprotein cholesterol in blood; in addition, the compounds and the compositions can also release nitric oxide, and reduce the onset risk of cardiovascular diseases by means of relaxing blood vessels, lowering blood pressure, inhibiting platelet adhesion and aggregation and maintaining vascular tension, and thus play an important role in preventing and treating the occurrence and development of cardiovascular diseases.
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公开(公告)号：US11801239B2
公开(公告)日：2023-10-31
申请号：US17523229
申请日：2021-11-10
发明人： Jian Ge , Yunfei Li , Lihong Lin , Dengxue Sun , Jiamiao Wang , Yijin Wang , Zhiyun Wang
CPC分类号： A61K31/445 , A61K9/0019 , A61K9/16 , A61K9/1688 , A61K47/02 , A61K47/26 , A61K47/34 , A61K47/38
摘要： A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals having an average particle size of 2-52 μm.
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