公开(公告)号：US20240342268A1

公开(公告)日：2024-10-17

申请号：US18682494

申请日：2022-08-04

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

Inventor： Longlong SI

IPC: A61K39/145 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005 ,  C12N15/86

CPC classification number: A61K39/145 ,  A61P37/04 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  C07K2319/95 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16152 ,  C12N2760/16162 ,  C12N2760/16171

Abstract: A recombinant virus containing a degron, a preparation method therefor, and an application thereof. At least one viral protein of the recombinant virus containing the degron contains at least one degron capable of being recognized by a protein degradation system of a host cell, wherein the degron comprises any one of or a combination of at least two of an amino acid sequence, a polypeptide, or a structural motif. Further provided are a nucleic acid molecule, a recombinant vector, a preparation method for the recombinant virus containing the degron, a preparation system for the recombinant virus containing the degron, a vaccine, an oncolytic virus, and a drug. The recombinant virus containing the degron can be recognized and degraded by the protein degradation system in the host cell, the replication capability is weakened or even removed, and after a corresponding vaccine, oncolytic virus or drug is prepared, a good effect and practical application value are achieved.