公开(公告)号：US10722559B2

公开(公告)日：2020-07-28

申请号：US15503223

申请日：2015-08-11

申请人： Shire Human Genetic Therapies, Inc.

发明人： Michael F. Concino ,  Bettina Strack-Logue ,  Muthuraman Meiyappan ,  Angela W. Norton ,  Bohong Zhang ,  Andrea Iskenderian ,  Lieh Yoon Low ,  Dianna Lundberg ,  Alla Romashko ,  Hicham Naimy

IPC分类号： A61K38/47 ,  A61K38/43 ,  A61K38/17 ,  A61K38/20 ,  A61K38/30 ,  C07K14/47 ,  C07K14/54 ,  C07K14/65 ,  C12N9/12

摘要： A targeted therapeutic including a lysosomal enzyme and a lysosomal targeting moiety that is a peptide containing at least one N-linked glycosylation site. Methods of producing the targeted therapeutic may include nucleotide acids encoding the same and host cells co-expressing GNPT. Pharmaceutical compositions comprising the targeted therapeutic and methods of using the same to treat a lysosomal storage disease.

公开(公告)号：US09597376B2

公开(公告)日：2017-03-21

申请号：US14830481

申请日：2015-08-19

申请人： Shire Human Genetic Therapies, Inc.

发明人： Omar L. Francone ,  Lin Guey ,  Kevin Holmes ,  Bruce Tangarone ,  Matthew Traylor ,  Lenore von Krusenstiern ,  Tracy Dowie ,  Lieh Yoon Low ,  Bohong Zhang ,  Muthuraman Meiyappan ,  Angela Norton ,  Bettina Strack-Logue ,  Dianna Lundberg ,  Michael F. Concino

IPC分类号： A61K38/46

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  C12N9/20 ,  C12Y301/01034

摘要： A lipoprotein lipase (LPL) protein for treating and/or preventing HTG and its associated diseases, including but not limited to acute pancreatitis (AP), and in particular, acute pancreatitis secondary to or exacerbated by hypertriglyceridemia, and hypertriglyceridemia and its associated diseases in general, including cardiovascular and metabolic diseases, endocrine disorders, and fat embolism syndrome.

公开(公告)号：US20170202929A1

公开(公告)日：2017-07-20

申请号：US15411559

申请日：2017-01-20

申请人： Shire Human Genetic Therapies, Inc.

发明人： Omar L. Francone ,  Lin Guey ,  Kevin Holmes ,  Bruce Tangarone ,  Matthew Traylor ,  Lenore von Krusenstiern ,  Tracy Dowie ,  Lieh Yoon Low ,  Bohong Zhang ,  Muthuraman Meiyappan ,  Angela Norton ,  Bettina Strack-Logue ,  Dianna Lundberg ,  Michael F. Concino

IPC分类号： A61K38/46 ,  C12N9/20 ,  A61K9/08 ,  A61K9/00 ,  A61K9/19

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  C12N9/20 ,  C12Y301/01034

摘要： A lipoprotein lipase (LPL) protein for treating and/or preventing HTG and its associated diseases, including but not limited to acute pancreatitis (AP), and in particular, acute pancreatitis secondary to or exacerbated by hypertriglyceridemia, and hypertriglyceridemia and its associated diseases in general, including cardiovascular and metabolic diseases, endocrine disorders, and fat embolism syndrome.

公开(公告)号：US20160051637A1

公开(公告)日：2016-02-25

申请号：US14830481

申请日：2015-08-19

申请人： SHIRE HUMAN GENETIC THERAPIES, INC.

发明人： Omar L. Francone ,  Lin Guey ,  Kevin Holmes ,  Bruce Tangarone ,  Matthew Traylor ,  Lenore von Krusenstiern ,  Tracy Dowie ,  Lieh Yoon Low ,  Bohong Zhang ,  Muthuraman Meiyappan ,  Angela Norton ,  Bettina Strack-Logue ,  Dianna Lundberg ,  Michael F. Concino

IPC分类号： A61K38/46

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  C12N9/20 ,  C12Y301/01034

摘要： A lipoprotein lipase (LPL) protein for treating and/or preventing HTG and its associated diseases, including but not limited to acute pancreatitis (AP), and in particular, acute pancreatitis secondary to or exacerbated by hypertriglyceridemia, and hypertriglyceridemia and its associated diseases in general, including cardiovascular and metabolic diseases, endocrine disorders, and fat embolism syndrome.

摘要翻译： 用于治疗和/或预防HTG及其相关疾病的脂蛋白脂肪酶（LPL）蛋白，包括但不限于急性胰腺炎（AP），特别是由高甘油三酯血症继发或加重的急性胰腺炎，以及高甘油三酯血症及其相关疾病 一般，包括心血管和代谢疾病，内分泌失调和脂肪栓塞综合征。