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公开(公告)号：US09932591B2
公开(公告)日：2018-04-03
申请号：US15105925
申请日：2014-12-18
申请人： Kelvin Lee , Abraham Lenhoff , Kristin Valente , Nick Levy , Yatin Gokarn
发明人： Kelvin Lee , Abraham Lenhoff , Kristin Valente , Nick Levy , Yatin Gokarn
IPC分类号： C12N15/11 , C12N15/113 , C07K16/00 , C12P21/02 , C12N9/20 , A61K38/17 , A61K38/39 , A61K38/42 , A61K38/44 , A61K38/45 , A61K38/48 , A61K38/52 , A61K47/26 , C12P21/00
CPC分类号： C12N15/1137 , A61K38/1709 , A61K38/1741 , A61K38/1761 , A61K38/1774 , A61K38/39 , A61K38/42 , A61K38/44 , A61K38/443 , A61K38/45 , A61K38/4813 , A61K38/482 , A61K38/488 , A61K38/52 , A61K47/26 , C07K16/00 , C12N9/20 , C12N2310/10 , C12N2310/14 , C12N2310/20 , C12P21/005 , C12P21/02 , C12Y104/03013 , C12Y111/01015 , C12Y205/01018 , C12Y207/04006 , C12Y207/11001 , C12Y301/01034 , C12Y304/16005 , C12Y304/21 , C12Y304/23005 , C12Y502/01008 , C12Y503/04001
摘要： The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
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公开(公告)号：US20180011094A1
公开(公告)日：2018-01-11
申请号：US15544103
申请日：2016-01-21
发明人： Dan Hoefner , Russ Warnick
IPC分类号： G01N33/573 , G01N33/92
CPC分类号： G01N33/573 , C12Y301/01034 , G01N33/6893 , G01N33/92 , G01N2800/32 , G01N2800/50
摘要： In various embodiments, the application relates to methods for assessment of cardiovascular disease (CVD) risk in a patient comprising comparing pre-heparin LPL (lipoprotein lipase) levels which are associated with protection from CVD to remnant lipoprotein cholesterol (RLP-C) and/or remnant lipoprotein triglyceride content (RLP-Tg).
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3.发明申请LIPOPROTEIN LIPASE FOR TREATMENT OF HYPERTRIGLYCERIDEMIC-RELATED CONDITIONS INCLUDING ACUTE PANCREATITIS 有权用于治疗包括急性胰腺炎的高血糖相关病症的利培酮公开(公告)号：US20160051637A1
公开(公告)日：2016-02-25
申请号：US14830481
申请日：2015-08-19
发明人： Omar L. Francone , Lin Guey , Kevin Holmes , Bruce Tangarone , Matthew Traylor , Lenore von Krusenstiern , Tracy Dowie , Lieh Yoon Low , Bohong Zhang , Muthuraman Meiyappan , Angela Norton , Bettina Strack-Logue , Dianna Lundberg , Michael F. Concino
IPC分类号： A61K38/46
CPC分类号： A61K38/465 , A61K9/0019 , A61K9/08 , A61K9/19 , C12N9/20 , C12Y301/01034
摘要： A lipoprotein lipase (LPL) protein for treating and/or preventing HTG and its associated diseases, including but not limited to acute pancreatitis (AP), and in particular, acute pancreatitis secondary to or exacerbated by hypertriglyceridemia, and hypertriglyceridemia and its associated diseases in general, including cardiovascular and metabolic diseases, endocrine disorders, and fat embolism syndrome.
摘要翻译： 用于治疗和/或预防HTG及其相关疾病的脂蛋白脂肪酶（LPL）蛋白，包括但不限于急性胰腺炎（AP），特别是由高甘油三酯血症继发或加重的急性胰腺炎，以及高甘油三酯血症及其相关疾病 一般，包括心血管和代谢疾病，内分泌失调和脂肪栓塞综合征。
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公开(公告)号：US20230234995A1
公开(公告)日：2023-07-27
申请号：US17781873
申请日：2020-12-01
申请人： LG CHEM, LTD
发明人： Byeong Eun MIN , Yeonchul KIM , Young Sam PARK , Saem JUNG
IPC分类号： C07K14/47 , C12N15/90 , C12N5/00 , C12N9/64 , C12N9/02 , C12N9/20 , C12N9/90 , C07K14/52 , C07K14/81 , C07K14/78 , C07K14/435
CPC分类号： C07K14/47 , C07K14/78 , C07K14/81 , C07K14/523 , C07K14/43595 , C12N5/00 , C12N9/20 , C12N9/0051 , C12N9/90 , C12N9/6472 , C12N15/907 , C12Y108/03002 , C12Y301/01034 , C12Y304/22001 , C12Y503/04001
摘要： The present invention relates to a CHO cell-derived protein secretory factor, an expression cassette in which a nucleic acid sequence encoding the protein secretory factor; and a gene encoding a target protein are operably linked, an expression vector comprising the expression cassette, a transformed cell into which the expression vector is introduced, and a method for producing a target protein using the transformed cell.
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公开(公告)号：US20160312226A1
公开(公告)日：2016-10-27
申请号：US15105925
申请日：2014-12-18
申请人： Kelvin LEE , Abraham LENHOFF , Kristen VALENTE , Nick LEVY , Yatin GOKARN
发明人： Kelvin LEE , Abraham LENHOFF , Kristen VALENTE , Nick LEVY , Yatin GOKARN
IPC分类号： C12N15/113 , A61K38/39 , A61K38/17 , A61K38/44 , C12P21/00 , A61K38/48 , A61K38/45 , A61K38/42 , A61K47/26 , C07K16/00 , A61K38/52
CPC分类号： C12N15/1137 , A61K38/1709 , A61K38/1741 , A61K38/1761 , A61K38/1774 , A61K38/39 , A61K38/42 , A61K38/44 , A61K38/443 , A61K38/45 , A61K38/4813 , A61K38/482 , A61K38/488 , A61K38/52 , A61K47/26 , C07K16/00 , C12N9/20 , C12N2310/10 , C12N2310/14 , C12N2310/20 , C12P21/005 , C12P21/02 , C12Y104/03013 , C12Y111/01015 , C12Y205/01018 , C12Y207/04006 , C12Y207/11001 , C12Y301/01034 , C12Y304/16005 , C12Y304/21 , C12Y304/23005 , C12Y502/01008 , C12Y503/04001
摘要： The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
摘要翻译： 本发明涉及一种生产稳定重组蛋白的方法，包括在培养基中培养非天然存在的宿主细胞以产生重组蛋白，以及制备包含重组蛋白和聚山梨酯的组合物。 由宿主细胞产生的内源性脂蛋白脂肪酶降低。 内源性脂蛋白脂肪酶以少量存在于组合物中，并且能够降解聚山梨醇酯。 本发明还涉及相关宿主细胞和组合物及其制备。
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6.发明申请Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same 审中-公开重组病毒及其用于治疗动脉粥样硬化和其他形式的冠状动脉疾病的方法，试剂和试剂盒，用于评估与之相似的易感性公开(公告)号：US20090257981A1
公开(公告)日：2009-10-15
申请号：US11802679
申请日：2007-05-24
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C12N9/20 , C12N15/86 , C12N2710/10343 , C12N2740/13043 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/44 , C12Q1/6858 , C12Q2600/156 , C12Y301/01034 , C12Q2535/131 , C12Q2525/131
摘要： Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant viruses, especially for the treatment or prevention of dyslipoproteinemia-related pathologies.
摘要翻译： 包含编码参与脂蛋白代谢的脂肪酶的异源DNA序列的重组病毒。 本发明还涉及在所述重组病毒的治疗中的制备和用途，特别是用于治疗或预防与脂蛋白血症相关的病症。
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7.发明申请公开(公告)号：US20050129724A1
公开(公告)日：2005-06-16
申请号：US11049649
申请日：2005-02-04
申请人： Jorge Plutzky , Ouliana Ziouzenkova
发明人： Jorge Plutzky , Ouliana Ziouzenkova
CPC分类号： A61K8/375 , A61K8/66 , A61K31/11 , A61K31/216 , A61K38/465 , A61Q5/006 , A61Q7/00 , A61Q19/005 , A61Q19/007 , C12Y301/01034 , A61K2300/00
摘要： The present invention is directed to compositions which include the enzyme lipoprotein lipase. These compositions may be applied topically to the skin of a person to prevent dryness or treat inflammation. In addition, the invention is directed to the use of fibrates to enhance the activity of lipoprotein lipase. The fibrates may be used orally to treat inflammation or enhance metabolic energy production.
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8.发明授权Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same 失效重组病毒及其用于治疗动脉粥样硬化和其他形式的冠状动脉疾病的方法，试剂和试剂盒，用于评估与之相似的易感性公开(公告)号：US06814962B1
公开(公告)日：2004-11-09
申请号：US09713268
申请日：2000-11-16
申请人： Patrick Benoit , Patrice Denefle , Michel Perricaudet , M. E. Suzanne Lewis , Michael R. Hayden
发明人： Patrick Benoit , Patrice Denefle , Michel Perricaudet , M. E. Suzanne Lewis , Michael R. Hayden
IPC分类号： A61K4800
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C12N9/20 , C12N15/86 , C12N2710/10343 , C12N2740/13043 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/44 , C12Q1/6858 , C12Q2600/156 , C12Y301/01034 , C12Q2535/131 , C12Q2525/131
摘要： Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant viruses, especially for the treatment or prevention of dyslipoproteinemia-related pathologies.
摘要翻译： 包含编码参与脂蛋白代谢的脂肪酶的异源DNA序列的重组病毒。 本发明还涉及在所述重组病毒的治疗中的制备和用途，特别是用于治疗或预防与脂蛋白血症相关的病症。
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公开(公告)号：US12123030B2
公开(公告)日：2024-10-22
申请号：US16302368
申请日：2017-05-18
申请人： ModernaTX, Inc.
发明人： Kerry Benenato , Stephen Hoge , Paolo Martini , Iain McFadyen , Vladimir Presnyak , Ellalahewage Sathyajith Kumarasinghe
CPC分类号： C12N9/20 , A61K9/1274 , A61K9/5123 , A61K47/14 , B82Y5/00 , B82Y30/00 , C12Y301/01034
摘要： The invention relates to mRNA therapy for the treatment of hyperlipidemia. mRNAs for use in the invention, when administered in vivo, encode human lipoprotein lipase (LPL), isoforms thereof, functional fragments thereof, and fusion proteins comprising LPL. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto, mRNA therapies of the invention increase and/or restore deficient levels of LPL expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of triglycerides associated with deficient LPL activity in subjects.
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公开(公告)号：US20180179574A1
公开(公告)日：2018-06-28
申请号：US15757074
申请日：2016-09-02
发明人： John B. Ancsin
IPC分类号： C12Q1/44
CPC分类号： C12Q1/44 , C12N9/20 , C12Y301/01034 , G01N2333/92 , G01N2800/044
摘要： Provided herein are systems (e.g., reagents, devices, etc.) and methods for characterization of hypertriglyceridemia (HTG) in a subject. In particular, systems and methods, are provided for identifying the specific deficiency(ies) leading to HTG, and selecting an appropriate strategy for the treatment of HTG based thereof.
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