公开(公告)号：US20040001897A1

公开(公告)日：2004-01-01

申请号：US10314165

申请日：2002-12-09

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Satoshi Amano ,  Yuki Ogura ,  Yukiko Matsunaga ,  Takanari Tsuda ,  Yukari Aoyama ,  Nobuyoshi Koga

IPC: A61K035/78 ,  C12N009/48

CPC classification number: A61K8/64 ,  A61K8/553 ,  A61K8/97 ,  A61K8/985 ,  A61K2800/782 ,  A61Q1/02 ,  A61Q19/00 ,  A61Q19/08

Abstract: The invention provides an epidermal basement membrane structure formation accelerating preparation and a skin external preparation comprising a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane. It also provides, as a means for producing artificial skin having an adequately formed basement membrane, an artificial skin-forming medium which comprises a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane and a matrix metalloprotease inhibitor, as well as a method for producing the same.

Abstract translation: 本发明提供了一种表皮基底膜结构形成促进制剂和皮肤外用制剂，其包含丝氨酸蛋白酶抑制剂和任选的表皮基底膜细胞外基质蛋白组分产生促进剂。 它还提供了用于生产具有充分形成的基底膜的人造皮肤的手段，人造皮肤形成培养基包括丝氨酸蛋白酶抑制剂和任选的表皮基底膜的细胞外基质蛋白组分的产生促进剂和基质 金属蛋白酶抑制剂，以及其制备方法。