公开(公告)号：US20220002253A1

公开(公告)日：2022-01-06

申请号：US17291662

申请日：2019-11-07

Applicant: SHOWA DENKO K.K.

Inventor： Motoki MURAI ,  Akira SHIBUYA

IPC: C07D239/557

Abstract: Provided is a method for producing an orotic acid derivative, the method comprising a condensation step of performing, under a basic condition, a condensation reaction between an orotic acid halide represented by General Formula (I) and a compound represented by General Formula (II) to generate an orotic acid derivative represented by General Formula (III); and a neutralization crystallization step of precipitating crystals of orotic acid by neutralization crystallization to separate a liquid containing the orotic acid derivative from the crystals of orotic acid, after the condensation step. In General Formula (I), (II), or (III), X is a halogen atom, and A is a group represented by General Formula (A-1) or (A-2). In General Formula (A-1) or (A-2), R1 is a hydrogen atom or an organic group, and R2 and R3 are each independently an organic group. In a case where R1 is an organic group, R1 and R2 may be bonded to each other to form a ring.

公开(公告)号：US20190161434A1

公开(公告)日：2019-05-30

申请号：US16320686

申请日：2017-07-25

Applicant: SHOWA DENKO K.K.

Inventor： Takanori AOKI ,  Akira SHIBUYA ,  Takamitsu KOBAYASHI ,  Hideo MIYATA ,  Shinya TSUKAMOTO ,  Manabu KUWAJIMA ,  Motoki MURAI

IPC: C07C227/18 ,  C07C229/08 ,  C07C231/02 ,  C07C233/04 ,  B01J21/06

Abstract: The present invention relates to a method for producing a specified α-amino acid, the method including allowing a specified α-amino acid amide and water to react with each other in the presence of a zirconium compound which contains zirconium and at least one metal element selected from the group consisting of lithium, nickel, copper, zinc, cesium, barium, hafnium, tantalum, cerium, and dysprosium.

公开(公告)号：US20210292273A1

公开(公告)日：2021-09-23

申请号：US16317988

申请日：2017-07-11

Applicant: SHOWA DENKO K.K.

Inventor： Takanori AOKI ,  Akira SHIBUYA ,  Takamitsu KOBAYASHI ,  Hideo MIYATA ,  Shinya TSUKAMOTO ,  Manabu KUWAJIMA ,  Motoki MURAI

IPC: C07C227/26

Abstract: Provided is a method for producing glycine, in which on synthesizing glycine from glycinonitrile, glycine can be obtained in a higher yield than that in the conventional method. The present invention relates to a method for producing glycine, including allowing glycinonitrile and water to react with each other in the presence of a cerium compound, optionally adding ammonia thereto, to obtain glycine.