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公开(公告)号：US20220056043A1
公开(公告)日：2022-02-24
申请号：US17416064
申请日：2020-02-10
发明人： GUIYING LI , Zejin YOU , Yun HE , Qiang TIAN , Hongmei SONG , Tongtong XUE , Jingyi WANG
IPC分类号： C07D495/04 , A61P35/00
摘要： The present invention relates to a nitrogen-containing fused ring compound, a preparation method and use thereof. Specifically, the present invention relates to a compound having the structure of Formula (X), a stereoisomer, tautomer or mixture thereof, a pharmaceutically acceptable salt, co-crystal, polymorph or solvate thereof, or a stable isotope derivative, metabolite or prodrug thereof. The compound of the invention may have the structure of Formula (I) or Formula (II). These compounds are useful for the treatment of an abnormal cell proliferation disease (e.g., cancer).
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公开(公告)号：US20200147062A1
公开(公告)日：2020-05-14
申请号：US16745206
申请日：2020-01-16
发明人： Yinong XIE , Zejin YOU , Zhiwen DENG , Jun ZHU , Ao WANG , Yan FENG , Dong LONG , Hong ZENG , Hongmei SONG , Qijun YE , Wei QI , Donghai SU , Lichun WANG , Jingyi WANG
IPC分类号： A61K31/437 , A61P35/00 , A61P29/00 , A61P19/02 , A61P37/00 , C07D487/04 , A61K31/519 , C07D471/04
摘要： The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, inflammatory diseases, autoimmune diseases, and cancers.
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公开(公告)号：US20190060291A1
公开(公告)日：2019-02-28
申请号：US16169780
申请日：2018-10-24
发明人： YINONG XIE , Zejin YOU , Zhiwen DENG , Jun ZHU , Ao WANG , Yan FENG , Dong LONG , Hong ZENG , Hongmei SONG , Qijun YE , Wei QI , Donghai SU , Lichun WANG , Jingyi WANG
IPC分类号： A61K31/437 , C07D487/04 , A61K31/519 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61K31/343 , A61K38/17 , A61K39/00
摘要： The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, inflammatory diseases, autoimmune diseases, and cancers.
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公开(公告)号：US20180289680A1
公开(公告)日：2018-10-11
申请号：US15767508
申请日：2016-12-08
发明人： Yinong XIE , Zejin YOU , Zhiwen DENG , Jun ZHU , Ao WANG , Yan FENG , Dong LONG , Hong ZHENG , Hongmei SONG , Qijun YE , Wei Qi , Donghai SU , Lichun WANG , Jingyi WANG
IPC分类号： A61K31/437 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： A61K31/437 , A61K31/343 , A61K31/519 , A61K38/1793 , A61K2039/505 , A61K2300/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , C07D487/04
摘要： The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, inflammatory diseases, autoimmune diseases, and cancers.
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