公开(公告)号：US20230219990A1

公开(公告)日：2023-07-13

申请号：US18016172

申请日：2021-07-15

申请人： SICHUAN UNIVERSITY ,  ACADEMY OF MILITARY MEDICAL SCIENCES ,  CHENGDU AUPONE PHARMACEUTICAL CO., LTD

发明人： Yong Qin ,  Wu Zhong ,  Fei Xue ,  Xiaoyu Liu ,  Yu Wang ,  Xiaohan Zhou ,  Bo Liu ,  Ke Wang ,  Likai Yang ,  Ruijie Zhou ,  Yaxin Xiao ,  Fanglin Xue ,  Minjie Zhang ,  Hao Song ,  Zhibing Zheng ,  Song Li

IPC分类号： C07H1/00 ,  C07F7/10

CPC分类号： C07H1/00 ,  C07F7/10

摘要： Disclosed is a method for preparing a C-nucleoside compound represented by Formula (III) or salt thereof. The present method has a high reaction yield, is simple to operate, uses a single metal reagent, has stable reaction temperature conditions, does not require frequent changes to the reaction system during the operation process, is suitable for scale-up synthesis, is suitable for large-scale production of Remdesivir, and has low costs.