公开(公告)号：US20200277289A1

公开(公告)日：2020-09-03

申请号：US16781803

申请日：2020-02-04

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael LUZZIO ,  Kathleen MCCARTHY ,  William HANEY

IPC: C07D451/14 ,  C07D451/04 ,  C07D403/14

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20230027684A1

公开(公告)日：2023-01-26

申请号：US17391356

申请日：2021-08-02

Applicant: Skyhawk Therapeutics, Inc.

Inventor： Michael LUZZIO ,  Brian LUCAS ,  Daniel Brian HORNE

IPC: C07D471/08 ,  C07D519/00

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20230054781A1

公开(公告)日：2023-02-23

申请号：US17388093

申请日：2021-07-29

Applicant: Skyhawk Therapeutics, Inc.

Inventor： Michael LUZZIO ,  Brian LUCAS

IPC: C07D451/14 ,  C07D451/06 ,  C07D519/00

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20230020922A1

公开(公告)日：2023-01-19

申请号：US17391620

申请日：2021-08-02

Applicant: Skyhawk Therapeutics, Inc.

Inventor： Michael LUZZIO ,  Brian LUCAS

IPC: C07D471/08

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20230008867A1

公开(公告)日：2023-01-12

申请号：US17391479

申请日：2021-08-02

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael LUZZIO ,  Brian LUCAS ,  Daniel Brian HORNE ,  Tiansheng WANG

IPC: C07D471/08 ,  C07D519/00

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20220403383A1

公开(公告)日：2022-12-22

申请号：US17227643

申请日：2021-04-12

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael LUZZIO ,  Kathleen MCCARTHY ,  William HANEY

IPC: C12N15/113 ,  C07D401/14 ,  C07D403/14 ,  C07D451/02 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08 ,  C07D491/08 ,  C07D451/04

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20230152257A1

公开(公告)日：2023-05-18

申请号：US16649697

申请日：2018-09-25

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Kathleen MCCARTHY ,  Michael LUZZIO

IPC: G01N24/08 ,  C12N15/11 ,  C07H21/04 ,  G01N33/53 ,  C12Q1/6816 ,  C12P19/34

CPC classification number: G01N24/088 ,  C12N15/11 ,  C07H21/04 ,  G01N33/5308 ,  C12Q1/6816 ,  C12P19/34

Abstract: Provided herein are structure-based screening platforms and methods to identify small molecules that can bind polynucleotides and/or complexes formed by polynucleotides and proteins. Structure-based screening platforms and methods to characterize interactions of small molecules with polynucleotides and/or with complexes formed by polynucleotides and proteins are also provided herein. Methods and compositions to identify small molecules that can bind polynucleotides and/or polynucleotide-protein complexes involved in RNA splicing are also provided herein.

公开(公告)号：US20210292316A1

公开(公告)日：2021-09-23

申请号：US17046245

申请日：2019-04-10

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael LUZZIO ,  Kathleen MCCARTHY

IPC: C07D451/14 ,  A61K45/06 ,  C07D451/04

Abstract: Described herein are splice modifying compounds affecting splicing of mRNA, such as pre-mRNA, expressed from the FOXM1 gene, compositions comprising thereof, and methods using the same.

公开(公告)号：US20200247799A1

公开(公告)日：2020-08-06

申请号：US16781524

申请日：2020-02-04

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael LUZZIO ,  Kathleen MCCARTHY ,  William HANEY

IPC: C07D451/02 ,  C07D451/14 ,  C07D403/14 ,  C07D487/08 ,  C07D401/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/08 ,  C07D471/08

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.