公开(公告)号：US20230068499A1

公开(公告)日：2023-03-02

申请号：US17388100

申请日：2021-07-29

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： MICHAEL LUZZIO ,  BRIAN LUCAS ,  TIANSHENG WANG ,  JUN FENG

IPC: C07D451/14 ,  C07D451/06 ,  C07D498/08 ,  C07D519/00

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US11530207B2

公开(公告)日：2022-12-20

申请号：US17046245

申请日：2019-04-10

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael Luzzio ,  Kathleen McCarthy

IPC: C07D451/02 ,  C07D451/04 ,  C07D451/14 ,  A61K31/501 ,  A61K45/06

Abstract: Described herein are splice modifying compounds affecting splicing of mRNA, such as pre-mRNA, expressed from the FOXM1 gene, compositions comprising thereof, and methods using the same.

公开(公告)号：US11129829B2

公开(公告)日：2021-09-28

申请号：US16813069

申请日：2020-03-09

Applicant: Skyhawk Therapeutics, Inc.

Inventor： Michael Luzzio ,  Kathleen McCarthy ,  Botao Liu

IPC: C12N15/11 ,  A61K31/501 ,  C12N15/113

Abstract: Described herein are methods of use of small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.

公开(公告)号：US20200277289A1

公开(公告)日：2020-09-03

申请号：US16781803

申请日：2020-02-04

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael LUZZIO ,  Kathleen MCCARTHY ,  William HANEY

IPC: C07D451/14 ,  C07D451/04 ,  C07D403/14

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US11603531B1

公开(公告)日：2023-03-14

申请号：US17502824

申请日：2021-10-15

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael Luzzio ,  Kathleen McCarthy ,  William Haney

IPC: C12N15/113 ,  C07D401/14 ,  C07D403/14 ,  C07D451/02 ,  C07D451/04 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/08 ,  C07D491/08 ,  C07D471/10

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20230054781A1

公开(公告)日：2023-02-23

申请号：US17388093

申请日：2021-07-29

Applicant: Skyhawk Therapeutics, Inc.

Inventor： Michael LUZZIO ,  Brian LUCAS

IPC: C07D451/14 ,  C07D451/06 ,  C07D519/00

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20230020922A1

公开(公告)日：2023-01-19

申请号：US17391620

申请日：2021-08-02

Applicant: Skyhawk Therapeutics, Inc.

Inventor： Michael LUZZIO ,  Brian LUCAS

IPC: C07D471/08

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20230008867A1

公开(公告)日：2023-01-12

申请号：US17391479

申请日：2021-08-02

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael LUZZIO ,  Brian LUCAS ,  Daniel Brian HORNE ,  Tiansheng WANG

IPC: C07D471/08 ,  C07D519/00

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US20220403383A1

公开(公告)日：2022-12-22

申请号：US17227643

申请日：2021-04-12

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael LUZZIO ,  Kathleen MCCARTHY ,  William HANEY

IPC: C12N15/113 ,  C07D401/14 ,  C07D403/14 ,  C07D451/02 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08 ,  C07D491/08 ,  C07D451/04

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

公开(公告)号：US11091475B2

公开(公告)日：2021-08-17

申请号：US16818590

申请日：2020-03-13

Applicant: SKYHAWK THERAPEUTICS, INC.

Inventor： Michael Luzzio ,  Kathleen McCarthy ,  William Haney

IPC: A61K31/501 ,  C07D451/02 ,  C07D491/08 ,  C07D403/14 ,  C07D451/14 ,  C07D471/04 ,  C07D401/14 ,  C07D487/08 ,  C07D471/08 ,  C07D471/10

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.