公开(公告)号：US3855233A

公开(公告)日：1974-12-17

申请号：US18364271

申请日：1971-09-24

申请人： SQUIBB & SONS INC

发明人： DOLFINI J ,  BOHME E ,  SLUSARCHYK W

IPC分类号： C07D499/21 ,  C07D499/42 ,  C07D99/14

CPC分类号： C07D499/42 ,  C07D499/21

摘要： Disclosed herein are penicillanic acids and derivatives thereof which are substituted in the 6-position, processes for preparing such compounds and the utility thereof. The compounds of the invention have been found to be useful as antibacterial agents.

摘要翻译： 本文公开了在6-位取代的青霉烷酸及其衍生物，制备这些化合物的方法及其用途。 已经发现本发明的化合物可用作抗菌剂。

公开(公告)号：US3840533A

公开(公告)日：1974-10-08

申请号：US26062072

申请日：1972-06-07

申请人： SQUIBB & SONS INC

发明人： DOLFINI J ,  BOHME E

IPC分类号： C07D501/18 ,  C07D501/57 ,  C07D99/24

CPC分类号： C07D501/18 ,  C07D501/57

摘要： 1. A COMPOUND HAVING THE FORMULA:

2-(R4-OOC-),3-(Y-CH2-),7-R3,7-(R9-CH=N-)-2-CEPHEM

WHEREIN R3 IS LOWER ALKYLTHIO; R9 IS SELECTED FROM THE GROUP CONSISTING OF PHENYL AND SUBSTITUTED PHENYL WHEREIN SAID SUBSTITUENT IS SELECTED FROM THE GROUP CONSISTING OF HALOGEN, LOWER ALKOXY, HYDROXY, NITRO, AMINO, AND LOWER ALKYL; R4 IS SELECTED FROM THW GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, TRICHLOROETHYL, BENZYL, METHOXYBENZYL, AND BENZHYDRYL; AND Y IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ACETOXY, PYRIDINIUM AND HYDROXY; AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.