公开(公告)号：US20250116673A1

公开(公告)日：2025-04-10

申请号：US18681966

申请日：2022-08-10

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Paul THOMAS ,  Mikhail POGORELYY ,  Anastasia MINERVINA

IPC: G01N33/68 ,  G01N33/50

Abstract: Disclosed are methods for identifying or determining whether a subject exhibits a CD4+ memory T cell response to SARS-CoV-2 infection or vaccination, assessing the efficacy of a SARS-CoV-2 vaccine, and developing personalized SARS-CoV-2 treatment plans by detecting the presence and/or quantity of a particular T cell receptor a chain that recognizes a specific Spike protein epitope.

公开(公告)号：US20250066852A1

公开(公告)日：2025-02-27

申请号：US18721777

申请日：2022-12-22

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Mikhail POGORELYY ,  Anastasia MINERVINA ,  Paul THOMAS

IPC: C12Q1/6876

Abstract: A kit and method for analyzing nucleic acid molecules encoding T cell receptor (TCR) chains from individual T cells are disclosed. In particular, a method for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding TCRs is provided.

公开(公告)号：US20230348585A1

公开(公告)日：2023-11-02

申请号：US17923029

申请日：2021-05-05

Applicant: St. Jude Children's Research Hospital, Inc. ,  Washington University

Inventor： Paul THOMAS ,  Jeremy Chase CRAWFORD ,  Emma Kaitlynn SLIGER ,  Aisha SOUQUETTE ,  Ali ELLEBEDY ,  Philip MUDD

IPC: C07K16/24 ,  A61K45/06

CPC classification number: C07K16/248 ,  A61K45/06

Abstract: Methods for treating or reducing the severity of a viral infection such as SARS-CoV-2 are provided, which include the administration of a cortisol antagonist preferably in combination with an IL-6 antagonist.

公开(公告)号：US20220259670A1

公开(公告)日：2022-08-18

申请号：US17616279

申请日：2020-06-30

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Pradyot DASH ,  Paul THOMAS

IPC: C12Q1/6886 ,  C12Q1/6806

Abstract: A kit and method for analyzing nucleic acid molecules encoding T cell receptor (TCR) a and β from individual T cells are disclosed. In particular, a method for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding TCRαβ is provided.

公开(公告)号：US20220251167A1

公开(公告)日：2022-08-11

申请号：US17618716

申请日：2020-06-19

Applicant: St. Jude Children's Research Hospital, Inc. ,  UNIVERSITY OF MARYLAND, BALTIMORE

Inventor： Paul THOMAS ,  Jeremy CRAWFORD ,  Allison KIRK ,  Anthony ZAMORA ,  Scott E. STROME

IPC: C07K14/725 ,  A61K39/00 ,  A61P35/00

Abstract: A vector harboring nucleic acids encoding a recombinant T cell receptor having antigenic specificity for a DnaJ heat shock protein family member B1-protein kinase cAMP-activated catalytic subunit alpha (DNAJB1-PRKACA) fusion protein is provided, as are host cells and a method for treating fibrolamellar hepatocellular carcinoma with the vector.