公开(公告)号：US20160347762A1

公开(公告)日：2016-12-01

申请号：US15024549

申请日：2014-09-29

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Richard E. Lee ,  Samanthi L. Waidyarachchi ,  David F. Bruhn ,  Jiuyu Liu ,  Zhong Zheng ,  Jason W. Rosch

IPC: C07D493/04 ,  A61K45/06 ,  A61K9/00 ,  A61K31/4433 ,  A61K31/381 ,  A61K31/497 ,  A61K31/4178 ,  A61K31/428 ,  A61K31/4045 ,  A61K31/4025 ,  A61K31/5377 ,  A61K31/357 ,  A61K31/427

CPC classification number: C07D493/04 ,  A61K9/0019 ,  A61K31/357 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4045 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4433 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06

Abstract: The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.

Abstract translation: 本发明涉及可用作抗菌剂的芳基取代氨基甲基壮观霉素类似物，其衍生物和相关化合物; 制备化合物的方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗抗菌感染的方法。

公开(公告)号：US10266544B2

公开(公告)日：2019-04-23

申请号：US15024549

申请日：2014-09-29

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Richard E. Lee ,  Samanthi L. Waidyarachchi ,  David F. Bruhn ,  Jiuyu Liu ,  Zhong Zheng ,  Jason W. Rosch

IPC: C07D493/04 ,  A61K9/00 ,  A61K31/357 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4045 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4433 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06

Abstract: The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.

公开(公告)号：US11547709B2

公开(公告)日：2023-01-10

申请号：US16957996

申请日：2018-12-26

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Suzanne Jackowski ,  Charles O. Rock ,  Richard E. Lee ,  Lalit Kumar Sharma ,  Mi Kyung Yun ,  Chitra Subramanian ,  Rajendra P. Tangallapally ,  Anne V. Edwards ,  Robert Zamboni ,  T. Jagadeeswar Reddy ,  Jiuyu Liu

IPC: A61K31/501 ,  A61P3/00 ,  A61K31/197 ,  A61K31/205

Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.