公开(公告)号：US11891378B2

公开(公告)日：2024-02-06

申请号：US16958022

申请日：2018-12-26

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Richard E. Lee ,  Rajendra P. Tangallapally ,  Charles O. Rock ,  Suzanne Jackowski ,  Anne V. Edwards ,  Mi Kyung Yun ,  Chitra Subramanian ,  Robert Zamboni ,  T. Jagadeeswar Reddy

IPC: C07D403/04 ,  A61K31/197

CPC classification number: C07D403/04 ,  A61K31/197

Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US10011589B2

公开(公告)日：2018-07-03

申请号：US15125451

申请日：2015-03-12

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Richard E. Lee ,  Philip T. Cherian ,  Julian G. Hurdle ,  Xiaoqian Wu

IPC: C07D403/14 ,  C07D403/12 ,  C07D403/06

CPC classification number: C07D403/14 ,  C07D403/06 ,  C07D403/12

Abstract: Compounds for the treatment of bacterial and parasitic infections which are hybrid compounds of compounds having antibacterial or antiparasitic activity and compounds that decrease the absorption of the hybrid compound from the gastrointestinal tract. The compounds are preferably for use against C. difficile infections and comprise a hybrid molecule of an anti-C. difficile compound such as a nitroimidazole and a tetramic acid derivative.

公开(公告)号：US20160347762A1

公开(公告)日：2016-12-01

申请号：US15024549

申请日：2014-09-29

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Richard E. Lee ,  Samanthi L. Waidyarachchi ,  David F. Bruhn ,  Jiuyu Liu ,  Zhong Zheng ,  Jason W. Rosch

IPC: C07D493/04 ,  A61K45/06 ,  A61K9/00 ,  A61K31/4433 ,  A61K31/381 ,  A61K31/497 ,  A61K31/4178 ,  A61K31/428 ,  A61K31/4045 ,  A61K31/4025 ,  A61K31/5377 ,  A61K31/357 ,  A61K31/427

CPC classification number: C07D493/04 ,  A61K9/0019 ,  A61K31/357 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4045 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4433 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06

Abstract: The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.

Abstract translation: 本发明涉及可用作抗菌剂的芳基取代氨基甲基壮观霉素类似物，其衍生物和相关化合物; 制备化合物的方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗抗菌感染的方法。

公开(公告)号：US10266544B2

公开(公告)日：2019-04-23

申请号：US15024549

申请日：2014-09-29

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Richard E. Lee ,  Samanthi L. Waidyarachchi ,  David F. Bruhn ,  Jiuyu Liu ,  Zhong Zheng ,  Jason W. Rosch

IPC: C07D493/04 ,  A61K9/00 ,  A61K31/357 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4045 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4433 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06

Abstract: The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.

公开(公告)号：US20170073332A1

公开(公告)日：2017-03-16

申请号：US15125451

申请日：2015-03-12

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Richard E. Lee ,  Philip T. Cherian ,  Julian G. Hurdle ,  Xiaoqian WU

IPC: C07D403/14 ,  C07D403/12 ,  C07D403/06

CPC classification number: C07D403/14 ,  C07D403/06 ,  C07D403/12

Abstract: Compounds for the treatment of bacterial and parasitic infections which are hybrid compounds of compounds having antibacterial or antiparasitic activity and compounds that decrease the absorption of the hybrid compound from the gastrointestinal tract. The compounds are preferably for use against C. difficile infections and comprise a hybrid molecule of an anti-C. difficile compound such as a nitroimidazole and a tetramic acid derivative.

Abstract translation: 用于治疗细菌和寄生虫感染的化合物，其是具有抗细菌或抗寄生虫活性的化合物的混合化合物和降低杂化化合物从胃肠道吸收的化合物。 所述化合物优选用于针对艰难梭菌感染，并且包含抗C的杂交分子。 艰难梭菌化合物如硝基咪唑和四聚酸衍生物。

公开(公告)号：US11547709B2

公开(公告)日：2023-01-10

申请号：US16957996

申请日：2018-12-26

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. ,  COA THERAPEUTICS, INC.

Inventor： Suzanne Jackowski ,  Charles O. Rock ,  Richard E. Lee ,  Lalit Kumar Sharma ,  Mi Kyung Yun ,  Chitra Subramanian ,  Rajendra P. Tangallapally ,  Anne V. Edwards ,  Robert Zamboni ,  T. Jagadeeswar Reddy ,  Jiuyu Liu

IPC: A61K31/501 ,  A61P3/00 ,  A61K31/197 ,  A61K31/205

Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.