公开(公告)号：US20220226380A1

公开(公告)日：2022-07-21

申请号：US17605639

申请日：2020-04-23

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Hongbo CHI ,  Jun WEI ,  Terrence GEIGER ,  Wenting ZHENG

IPC: A61K35/17 ,  C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  C12N9/10 ,  C12N9/16 ,  A61P35/00 ,  C07K14/47 ,  A61K38/46 ,  A61K31/7088 ,  C12N15/86 ,  C07K16/28 ,  C07K14/705 ,  C07K14/725

Abstract: The present application provides methods of enhancing T cell function (e.g., expansion, persistence and/or effector functions), particularly by genetic modification of the Regnase-1, Batf, and additional genes (alone or in combination). The application also provides modified T cells manufactured using the methods provided by this invention and related pharmaceutical compositions. The application further provides methods of using the modified T cells for treating a disease (e.g., a cancer or an infectious disease).