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公开(公告)号：US11247378B2
公开(公告)日：2022-02-15
申请号：US16095306
申请日：2017-04-24
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
IPC分类号： B29C48/405 , B29C48/57 , B29C48/64 , B29B9/16 , B29B7/48 , B29B9/06 , B29B7/94 , B29B9/08 , B29C48/04 , B29C48/625 , B29C48/80
摘要： A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.
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公开(公告)号：US11465327B1
公开(公告)日：2022-10-11
申请号：US15760583
申请日：2017-04-24
发明人： Indu Bhushan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Aravind Kumar Gurram , Babu Padmanabhan
IPC分类号： B29C48/655 , A61K9/14 , A61K31/216 , B29C48/68 , B29C48/80 , B29C48/40
摘要： A fractional lobe processor comprises a barrel with heating and cooling means having two parallel intersecting bores of equal diameter, wherein the centre distance between the two bores is lesser than the diameter of the bore; a shaft coupled with a plurality of screw elements to form a screw within each bore, wherein the screws are intermeshing and form at least three zones within the barrel, the zones comprising an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a feed comprising an active substance and/or an excipient, a melt zone consisting of only fractional lobe elements for melting the active substance and/or an excipient to form a viscous mass or melt, and a discharge zone, wherein the melt zone is located before the discharge zone and after the intake zone; and wherein the melt zone has a plurality of fractional lobe elements on each shaft.
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公开(公告)号：US20190134875A1
公开(公告)日：2019-05-09
申请号：US16095306
申请日：2017-04-24
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
摘要： A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.
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公开(公告)号：US11247380B2
公开(公告)日：2022-02-15
申请号：US16373187
申请日：2019-04-02
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
IPC分类号： B29C48/405 , B29C48/57 , B29C48/64 , B29B9/16 , B29B7/48 , B29B9/06 , B29B7/94 , B29B9/08 , B29C48/04 , B29C48/625 , B29C48/80
摘要： Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.
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公开(公告)号：US11247379B2
公开(公告)日：2022-02-15
申请号：US16373178
申请日：2019-04-02
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
IPC分类号： B29C48/405 , B29C48/57 , B29C48/64 , B29B9/16 , B29B7/48 , B29B9/06 , B29B7/94 , B29B9/08 , B29C48/04 , B29C48/625 , B29C48/80
摘要： Methods for granulating powder in a single piece of equipment include at least the following: (a) continuously introducing the powder and a granulating fluid to the single piece of equipment; (b) passing the powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules; (c) passing the wet granules through a drying zone of the single piece of equipment; (d) optionally passing granules through a discharge zone of the single piece of equipment; and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.
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公开(公告)号：US20190263043A1
公开(公告)日：2019-08-29
申请号：US16373187
申请日：2019-04-02
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
摘要： Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.
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