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公开(公告)号：US11576855B2
公开(公告)日：2023-02-14
申请号：US17445918
申请日：2021-08-25
发明人： Babu Padmanabhan , Rakshit Shetty , Vijay Kulkarni , Himadri Sen , Indu Bhushan
IPC分类号： A61K9/46 , A61K31/546 , A61K9/16 , A61K45/06 , A61K9/00 , A61K9/20 , A61K31/198 , A61K31/616
摘要： The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.
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公开(公告)号：US11465327B1
公开(公告)日：2022-10-11
申请号：US15760583
申请日：2017-04-24
发明人： Indu Bhushan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Aravind Kumar Gurram , Babu Padmanabhan
IPC分类号： B29C48/655 , A61K9/14 , A61K31/216 , B29C48/68 , B29C48/80 , B29C48/40
摘要： A fractional lobe processor comprises a barrel with heating and cooling means having two parallel intersecting bores of equal diameter, wherein the centre distance between the two bores is lesser than the diameter of the bore; a shaft coupled with a plurality of screw elements to form a screw within each bore, wherein the screws are intermeshing and form at least three zones within the barrel, the zones comprising an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a feed comprising an active substance and/or an excipient, a melt zone consisting of only fractional lobe elements for melting the active substance and/or an excipient to form a viscous mass or melt, and a discharge zone, wherein the melt zone is located before the discharge zone and after the intake zone; and wherein the melt zone has a plurality of fractional lobe elements on each shaft.
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公开(公告)号：US10792634B2
公开(公告)日：2020-10-06
申请号：US15747021
申请日：2016-08-01
发明人： Radhika Ghike , Vijay Kulkarni , Indu Bhushan , Himadri Sen , Babu Padmanabhan , Vinay Rao
IPC分类号： B01J2/20 , B29C48/40 , B29C48/92 , B01J2/28 , B01J2/30 , A61K9/16 , A61J3/02 , B29B9/06 , B29C48/59 , B29C48/57 , B29C48/04
摘要： A process for preparing granules is disclosed. The process comprises the steps of feeding the input material for granulation in a processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and collecting the granules from a discharge zone of the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.
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公开(公告)号：US20190134875A1
公开(公告)日：2019-05-09
申请号：US16095306
申请日：2017-04-24
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
摘要： A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.
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公开(公告)号：US20170252295A1
公开(公告)日：2017-09-07
申请号：US15512515
申请日：2015-03-26
发明人： Babu Padmanabhan , Rakshit Shetty , Vijay Kulkarni , Himadri Sen , Indu Bhushan
IPC分类号： A61K9/46 , A61K9/00 , A61K31/616 , A61K31/546 , A61K31/198 , A61K9/16 , A61K9/20
CPC分类号： A61K9/0007 , A61K9/0053 , A61K9/1611 , A61K9/1617 , A61K9/1682 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K31/198 , A61K31/546 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.
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公开(公告)号：US20230226723A1
公开(公告)日：2023-07-20
申请号：US18016246
申请日：2021-07-14
发明人： Babu Padmanabhan , Indu Bhushan , Vinay Rao
摘要： A continuous granulation system for obtaining conditioned granules is disclosed. The system comprises a processor configured to produce a continuous flow of granules at an outlet of the processor. The system also comprises a collection chamber positioned downstream from the processor and configured to collect the granules from the outlet. Further, the system comprises an air displacement device coupled to the collection chamber and configured to create a unidirectional flow of air at the outlet in a direction of the granules exiting the processor and away from the outlet. The unidirectional flow of air conditions the granules obtained in the collection chamber. A continuous granulation method and a continuous granule collection system for obtaining the conditioned granules is also disclosed.
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公开(公告)号：US11247378B2
公开(公告)日：2022-02-15
申请号：US16095306
申请日：2017-04-24
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
IPC分类号： B29C48/405 , B29C48/57 , B29C48/64 , B29B9/16 , B29B7/48 , B29B9/06 , B29B7/94 , B29B9/08 , B29C48/04 , B29C48/625 , B29C48/80
摘要： A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.
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公开(公告)号：US10213948B2
公开(公告)日：2019-02-26
申请号：US15920133
申请日：2018-03-13
IPC分类号： A61K9/16 , A61K9/20 , B29C47/00 , B29C47/40 , B29C47/60 , B29C47/80 , B29K91/00 , B29K105/00
摘要： A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.
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公开(公告)号：US20180214835A1
公开(公告)日：2018-08-02
申请号：US15747021
申请日：2016-08-01
发明人： Radhika Ghike , Vijay Kulkarni , Indu Bhushan , Himadri Sen , Babu Padmanabhan , Vinay Rao
摘要： The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also discl
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公开(公告)号：US11850567B2
公开(公告)日：2023-12-26
申请号：US17007641
申请日：2020-08-31
发明人： Radhika Ghike , Vijay Kulkarni , Indu Bhushan , Himadri Sen , Babu Padmanabhan , Vinay Rao
IPC分类号： B01J2/20 , B29C48/92 , A61K9/16 , A61J3/02 , B29C48/405 , B29C48/40 , B01J2/28 , B01J2/30 , B29B9/06 , B29C48/57 , B29C48/04 , B29C48/59
CPC分类号： B01J2/20 , A61J3/02 , A61K9/1652 , A61K9/1694 , B01J2/28 , B01J2/30 , B29C48/40 , B29C48/405 , B29C48/92 , B29B9/06 , B29C48/04 , B29C48/57 , B29C48/59 , B29C2948/926 , B29C2948/92723
摘要： A co-rotating twin screw processor for preparing dry granules including an input zone having one or more powder feeders for feeding an input material into the processor, a steam feeder configured to introduce steam as a granulation activating agent in to the processor, a granulation zone for granulating the input material in the presence of steam to form granules, a controller configured to control operation and feed rate of at least one of the powder feeder or the steam feeder such that 2.5 to 5 percent w/w of the steam with respect to the input material is available for granulation, and a discharge zone haring a non-extruding opening for collecting dry granules.
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