公开(公告)号：US20240374654A2

公开(公告)日：2024-11-14

申请号：US16980339

申请日：2019-03-11

Applicant: STEMCELL TECHNOLOGIES CANADA INC.

Inventor： Scott LOUGHHEAD ,  LeeAnn TALARICO ,  Alfonso VICENTE-SUAREZ ,  Matt BOOTY ,  Howard BERNSTEIN ,  Katarina BLAGOVIC ,  Armon SHAREI ,  Kelan HLAVATY

IPC: A61K35/74 ,  A61K39/02 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28

Abstract: The present application provides T cells comprising an antigen and an adjuvant, methods of manufacturing such T cells, and methods of using such T cells, such as for modulating an immune response in an individual.

公开(公告)号：US20250108071A1

公开(公告)日：2025-04-03

申请号：US18978710

申请日：2024-12-12

Applicant: Stemcell Technologies Canada Inc.

Inventor： Jonathan B. GILBERT ,  Bu WANG ,  Scott LOUGHHEAD ,  Howard BERNSTEIN ,  Armon R. SHAREI ,  Finola MOORE

IPC: A61K35/18 ,  A61K35/19 ,  A61K39/00 ,  A61K39/385 ,  A61P37/06 ,  C12M1/12 ,  C12M3/06 ,  C12N5/078 ,  C12N15/85 ,  C12N15/87

Abstract: The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.

公开(公告)号：US20250115854A1

公开(公告)日：2025-04-10

申请号：US18983907

申请日：2024-12-17

Applicant: STEMCELL TECHNOLOGIES CANADA INC.

Inventor： Maisam DADGAR ,  Tarek ABDELJAWAD ,  Howard BERNSTEIN

IPC: C12M1/42 ,  B01L3/00 ,  C12M3/06 ,  G01N1/31

Abstract: A system for delivering a payload to a cell that includes: a platform supporting an input container, an output container, and a receiver for receiving all or part of a disposable assembly, the disposable assembly including a preparation vessel and a constriction cartridge. The preparation vessel holds a cell suspension as it is prepared for passage through one or more cell-deforming constrictions, and the constriction cartridge houses a component that includes the one or more cell deforming constrictions. Passage through the cell-deforming constrictions causes perturbations in cell membranes to allow entry of a payload into the cells. The system includes one or more processors configured to receive input from a user and to automatically control pressure, temperature, agitation, and/or flow of the cell suspension as it passes through the input container, through the preparation vessel, through the constriction cartridge, and to the output container.