公开(公告)号：US20150141273A1

公开(公告)日：2015-05-21

申请号：US14396522

申请日：2013-04-26

Applicant: STICHTING VU-VUMC

Inventor： Linda Janna Willemien Bosch ,  Meike De Wit ,  Beatriz Pinto Morais de Carvalho ,  Remond Johnnes Adriaan Fijneman ,  Gerrit Albert Meijer ,  Comelia Ramona Jimenez ,  Sander Rogier Piersma ,  Viet Thang Pham ,  Gideon Oudgenoeg

IPC: G01N33/68 ,  G01N33/574

CPC classification number: G01N33/57419 ,  G01N33/6848 ,  G01N2500/10 ,  G01N2570/00 ,  G01N2800/7028

Abstract: The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individual is at risk of suffering from or is suffering from colorectal cancer. The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.

Abstract translation: 本发明提供了筛选结肠直肠癌的方法，该方法包括：从个体中筛选一种或多种选自表1和/或表6中定义的组的生物标志物的生物样品，其中存在或增加表达 一个或多个相对于对照样品的生物标志物表明个体处于患有或正在患有结肠直肠癌的风险中。 本发明还提供适用于本发明方法的阵列和试剂盒，治疗结肠直肠癌的方法和用于治疗癌症的方法中的治疗剂。