公开(公告)号：US20220002263A1

公开(公告)日：2022-01-06

申请号：US17291113

申请日：2019-11-05

Applicant: STUDIENGESELLSCHAFT KOHLE MBH

Inventor： Tobias RITTER ,  Florian BERGER

IPC: C07D339/08

Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.

公开(公告)号：US20220073552A1

公开(公告)日：2022-03-10

申请号：US17257387

申请日：2019-07-03

Applicant: STUDIENGESELLSCHAFT KOHLE MBH

Inventor： Tobias RITTER ,  Henrick Jens RICKMEIER

IPC: C07F17/02 ,  A61B6/03 ,  C07K1/13

Abstract: The present invention refers to reagents and methods for preparing a peptide sequence having a [18F]fluoro-aromatic amino acid side which may be further substituted, in particular a 4-[18F]fluoro-phenylalanine side chain in peptide sequences, by chemoselective radio-deoxyfluorination of an aromatic amino acid residue, in particular a tyrosine residue using a traceless-activating group and the reagents used in said process.

公开(公告)号：US20230227425A1

公开(公告)日：2023-07-20

申请号：US18099060

申请日：2023-01-19

Applicant: STUDIENGESELLSCHAFT KOHLE MBH

Inventor： Tobias RITTER ,  Florian BERGER

IPC: C07D339/08

CPC classification number: C07D339/08

Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.

公开(公告)号：US20200369583A1

公开(公告)日：2020-11-26

申请号：US16635266

申请日：2018-07-10

Applicant: STUDIENGESELLSCHAFT KOHLE MBH ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Tobias RITTER ,  Constanze NEUMANN ,  Mohammad Hassan BEYZAVI ,  Martin Georg STREBL-BANTILLO ,  Debashis MANDAL

IPC: C07C17/16 ,  C07C231/12 ,  C07B59/00 ,  C07D451/02

Abstract: The present invention refers to a process for transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for positron emission tomography (PET) imaging.

公开(公告)号：US20200181068A1

公开(公告)日：2020-06-11

申请号：US16613822

申请日：2018-05-08

Applicant: STUDIENGESELLSCHAFT KOHLE MBH

Inventor： Tobias RITTER ,  Fei YE

IPC: C07C253/12 ,  B01J31/24

Abstract: The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles and the catalyst used in the present process.