公开(公告)号：US20150190380A1

公开(公告)日：2015-07-09

申请号：US14461271

申请日：2014-08-15

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Daniel C. Adelman ,  Jeffrey A. Silverman ,  Glenn Michelson ,  Caroline Dame Scatena

IPC: A61K31/4375 ,  C07D417/14

CPC classification number: A61K31/4375 ,  A61K31/513 ,  A61K31/7068 ,  C07D417/14 ,  A61K2300/00

Abstract: Methods of treating, preventing or managing hematologic disorders, such as leukemia are disclosed. The methods encompass the administration of SNS-595. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with Ara-C. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.

Abstract translation: 公开了治疗，预防或治疗血液系统疾病如白血病的方法。 这些方法包括SNS-595的管理。 还提供了使用化合物与化疗，放射治疗，激素治疗，生物治疗或免疫治疗的治疗方法。 在某些实施方案中，治疗方法包括与Ara-C组合施用SNS-595。 还公开了适用于该方法的药物组合物和单一单位剂型。

公开(公告)号：US20160361302A1

公开(公告)日：2016-12-15

申请号：US14996025

申请日：2016-01-14

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Daniel C. Adelman ,  Jeffrey A. Silverman

IPC: A61K31/4375

CPC classification number: A61K31/4375 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/337 ,  A61K31/395 ,  A61K31/407 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/52 ,  A61K31/555 ,  A61K31/585 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K33/24 ,  A61K38/15 ,  A61K38/1816 ,  A61K41/00 ,  A61K45/06 ,  A61K47/12 ,  C07D471/04 ,  F24S10/70 ,  F24S50/40 ,  F24S60/30 ,  F24S80/60 ,  H01L31/0547 ,  H02S40/38 ,  Y02E10/40 ,  Y02E10/52 ,  A61K2300/00

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

公开(公告)号：US20140378505A1

公开(公告)日：2014-12-25

申请号：US14171673

申请日：2014-02-03

Applicant: SUNESIS PHARMACEUTICALS, INC.

Inventor： Daniel C. ADELMAN ,  Jeffrey A. Silverman

IPC: A61K31/4375 ,  A61K45/06

Abstract: The present invention relates to SNS-595 and of treating cancer using the same.

Abstract translation: 本发明涉及SNS-595和使用其治疗癌症。

公开(公告)号：US20140205679A1

公开(公告)日：2014-07-24

申请号：US13972800

申请日：2013-08-21

Applicant: SUNESIS PHARMACEUTICALS, INC.

Inventor： Jeffrey A. Silverman

IPC: A61K31/4375 ,  A61K31/282 ,  A61K45/06 ,  A61K33/24

CPC classification number: A61K31/4375 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/555 ,  A61K31/7068 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods of treating, preventing or managing cancers are disclosed. The methods encompass the administration of SNS-595 in combination with a second active agent. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with cisplatin, carboplatin, gemcitabine or a combination thereof.

Abstract translation: 公开了治疗，预防或治疗癌症的方法。 所述方法包括与第二活性剂组合施用SNS-595。 在某些实施方案中，治疗方法包括与顺铂，卡铂，吉西他滨或其组合组合施用SNS-595。

公开(公告)号：US09757363B2

公开(公告)日：2017-09-12

申请号：US14996025

申请日：2016-01-14

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Daniel C. Adelman ,  Jeffrey A. Silverman

IPC: A61K31/4375 ,  A61K9/00 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/555 ,  A61K38/18 ,  A61K41/00 ,  A61K45/06 ,  A61K31/7068 ,  C07D471/04 ,  A61K47/12

CPC classification number: A61K31/4375 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/337 ,  A61K31/395 ,  A61K31/407 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/52 ,  A61K31/555 ,  A61K31/585 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K33/24 ,  A61K38/15 ,  A61K38/1816 ,  A61K41/00 ,  A61K45/06 ,  A61K47/12 ,  C07D471/04 ,  F24S10/70 ,  F24S50/40 ,  F24S60/30 ,  F24S80/60 ,  H01L31/0547 ,  H02S40/38 ,  Y02E10/40 ,  Y02E10/52 ,  A61K2300/00

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

公开(公告)号：US20170119745A1

公开(公告)日：2017-05-04

申请号：US15173506

申请日：2016-06-03

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Daniel C. Adelman ,  Jeffrey A. Silverman ,  Glenn Michelson ,  Caroline Dame Scatena

IPC: A61K31/4375 ,  A61K31/7068

CPC classification number: A61K31/4375 ,  A61K31/513 ,  A61K31/7068 ,  C07D417/14 ,  A61K2300/00

Abstract: Methods of treating, preventing or managing hematologic disorders, such as leukemia are disclosed. The methods encompass the administration of SNS-595. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with Ara-C. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.

公开(公告)号：US20170101404A1

公开(公告)日：2017-04-13

申请号：US15156230

申请日：2016-05-16

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Daniel C. Adelman ,  Marc J. Evanchik ,  Anantha Sudhakar ,  Jeffrey William Jacobs ,  Jeffrey A. Silverman

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4375 ,  A61K31/4745 ,  C07D417/14 ,  A61K2300/00

Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.

公开(公告)号：US20140205680A1

公开(公告)日：2014-07-24

申请号：US14056877

申请日：2013-10-17

Applicant: SUNESIS PHARMACEUTICALS, INC.

Inventor： Daniel C. Adelman ,  Jeffrey A. Silverman ,  Michelle Arkin ,  Jennifer Hyde ,  Duncan Walker ,  Jasmin Wright

IPC: A61K31/4375 ,  A61K45/06

CPC classification number: A61K31/4375 ,  A61K31/513 ,  A61K45/06

Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.

Abstract translation: 公开了治疗，预防或治疗癌症的方法，包括某些白血病。 该方法包括给予对映体纯的（+） - 1,4-二氢-7 - [（3S，4S）-3-甲氧基-4-（甲基氨基）-1-吡咯烷基] -4-氧代-1-（2 -1,3-噻唑基）-1,8-二氮杂萘-3-羧酸。 还提供了使用化合物与化疗，放射治疗，激素治疗，生物治疗或免疫治疗的治疗方法。 还公开了适用于该方法的药物组合物和单一单位剂型。

公开(公告)号：US20180098975A1

公开(公告)日：2018-04-12

申请号：US15714988

申请日：2017-09-25

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Daniel C. Adelman ,  Jeffrey A. Silverman ,  Michelle Arkin ,  Jennifer Hyde ,  Duncan Walker ,  Jasmin Wright

IPC: A61K31/4375 ,  A61K45/06 ,  A61K31/513

CPC classification number: A61K31/4375 ,  A61K31/513 ,  A61K45/06

Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.

公开(公告)号：US09676774B2

公开(公告)日：2017-06-13

申请号：US15156230

申请日：2016-05-16

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Daniel C. Adelman ,  Marc J. Evanchik ,  Anantha Sudhakar ,  Jeffrey William Jacobs ,  Jeffrey A. Silverman

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4375 ,  A61K31/4745 ,  C07D417/14 ,  A61K2300/00

Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.