公开(公告)号：US10570156B2

公开(公告)日：2020-02-25

申请号：US15818044

申请日：2017-11-20

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： John Emmerson Campbell ,  Philip Wendell Jones ,  Michael Charles Hewitt

IPC: A61K31/437 ,  C07D471/04 ,  C07D519/00 ,  A61K45/06 ,  C07D487/04 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5383

Abstract: Provided herein are cyclic nucleotide phosphodiesterase inhibitors of Formula (I) of claim 1, and pharmaceutical compositions thereof, useful for the treatment of, for example, central nervous system and metabolic diseases and disorder.

公开(公告)号：US09856274B2

公开(公告)日：2018-01-02

申请号：US14884397

申请日：2015-10-15

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： John Emmerson Campbell ,  Philip Jones ,  Michael Charles Hewitt

IPC: A61K31/4353 ,  C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5383

CPC classification number: C07D519/00 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5383 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

Abstract: Provided herein are substituted pyrazolopyridine compounds, and pharmaceutical compositions thereof, useful for the treatment of, for example, central nervous system and metabolic diseases and disorder.

公开(公告)号：US10562916B2

公开(公告)日：2020-02-18

申请号：US15787880

申请日：2017-10-19

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： John Emmerson Campbell ,  Michael Charles Hewitt ,  Philip Xinhe Jones ,  Linghong Xie

IPC: A61K31/498 ,  C07D241/40 ,  C07D498/06 ,  C07D401/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D491/056 ,  C07D498/14 ,  C07D519/00 ,  C07D403/06 ,  C07D401/14 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D417/06 ,  C07D498/04 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4709 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5383 ,  C07D233/58 ,  C07D471/06

Abstract: Provided herein are cyclic nucleotide phosphodiesterase inhibitors, and pharmaceutical compositions thereof, useful for the treatment of, for example, central nervous system and metabolic diseases and disorder.

公开(公告)号：US10189825B2

公开(公告)日：2019-01-29

申请号：US14377673

申请日：2013-02-08

Applicant: Sunovion Pharmaceuticals, Inc.

Inventor： John Emmerson Campbell ,  Una Campbell ,  Taleen G. Hanania ,  Liming Shao

IPC: C07D409/04 ,  C07D405/04 ,  C07D495/04 ,  C07D491/048 ,  C07D409/14

Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US10894033B2

公开(公告)日：2021-01-19

申请号：US16791118

申请日：2020-02-14

Applicant: Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

Inventor： Liming Shao ,  John Emmerson Campbell ,  Michael Charles Hewitt ,  Una Campbell ,  Taleen G. Hanania

IPC: A61K31/381 ,  C07D277/60 ,  C07D333/54 ,  C07D333/76 ,  A61K45/06 ,  C07D495/04 ,  C07D495/20 ,  A61K31/435 ,  A61K31/55 ,  C07D333/78

Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US09670230B2

公开(公告)日：2017-06-06

申请号：US14646888

申请日：2013-11-25

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： John Emmerson Campbell ,  Philip Jones

IPC: C07D519/00 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/5383 ,  A61K31/553

CPC classification number: C07D519/00 ,  A61K31/4985 ,  A61K31/5383 ,  A61K31/553 ,  C07D487/04

Abstract: Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

公开(公告)号：US20150291626A1

公开(公告)日：2015-10-15

申请号：US14646888

申请日：2013-11-25

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： John Emmerson Campbell ,  Philip Jones

IPC: C07D519/00 ,  A61K31/553 ,  A61K31/5383 ,  C07D487/04 ,  A61K31/4985

CPC classification number: C07D519/00 ,  A61K31/4985 ,  A61K31/5383 ,  A61K31/553 ,  C07D487/04

Abstract: Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

Abstract translation: 本文提供了杂芳基化合物，其合成方法，包含该化合物的药物组合物及其用途。 在一个实施方案中，本文提供的化合物可用于治疗，预防和/或治疗各种疾病，例如CNS障碍和代谢紊乱，包括但不限于例如神经障碍，精神病，精神分裂症，肥胖症， 和糖尿病。

公开(公告)号：US20150031709A1

公开(公告)日：2015-01-29

申请号：US14377673

申请日：2013-02-08

Applicant: Sunovion Pharmaceuticals, Inc.

Inventor： John Emmerson Campbell ,  Una Campbell ,  Taleen G. Hanania ,  Liming Shao

IPC: C07D409/04 ,  C07D409/14 ,  C07D491/048 ,  C07D405/04 ,  C07D495/04

CPC classification number: C07D409/04 ,  C07D405/04 ,  C07D409/14 ,  C07D491/048 ,  C07D495/04

Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Abstract translation: 本文提供噻吩化合物，其合成方法，包含该化合物的药物组合物及其使用方法。 本文提供的化合物可用于治疗，预防和/或治疗各种神经障碍，包括但不限于精神病和精神分裂症。

公开(公告)号：US20140288062A1

公开(公告)日：2014-09-25

申请号：US14298691

申请日：2014-06-06

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： John Emmerson Campbell ,  Philip Jones ,  Michael Charles Hewitt

IPC: C07D519/00 ,  A61K31/4985 ,  C07D487/04 ,  A61K31/4745 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/5383 ,  A61K31/519

CPC classification number: C07D519/00 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5383 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

Abstract: Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

Abstract translation: 本文提供了杂芳基化合物，其合成方法，包含该化合物的药物组合物及其用途。 在一个实施方案中，本文提供的化合物可用于治疗，预防和/或管理各种疾病，例如CNS障碍和代谢紊乱，包括但不限于例如神经障碍，精神病，精神分裂症，肥胖症， 和糖尿病。

公开(公告)号：US10556890B2

公开(公告)日：2020-02-11

申请号：US15851836

申请日：2017-12-22

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： John Emmerson Campbell ,  Una Campbell ,  Taleen G. Hanania ,  Liming Shao

IPC: C07D409/04 ,  C07D409/14 ,  C07D491/048 ,  C07D495/04 ,  C07D405/04

Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.