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公开(公告)号：US09351954B2
公开(公告)日：2016-05-31
申请号：US14205859
申请日：2014-03-12
发明人： Liming Shao , John Emmerson Campbell , Michael Charles Hewitt , Una Campbell , Taleen G. Hanania
IPC分类号： C07D495/02 , C07D233/00 , C07D403/02 , C07D403/14 , C07D231/00 , C07D487/00 , C07D487/02 , C07D405/00 , C07D409/00 , C07D411/00 , A61K31/415 , A61K31/40 , A61K31/48 , A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
CPC分类号： A61K31/381 , A61K31/435 , A61K31/55 , A61K45/06 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
摘要翻译： 本文提供多环化合物，其合成方法，包含该化合物的药物组合物及其使用方法。 例如，本文公开的是具有下面所示的式（IIa）的化合物或其药学上可接受的盐或立体异构体，其中变量在本文中定义。 本文提供的化合物可用于治疗，预防和/或治疗各种神经障碍，包括但不限于精神病和精神分裂症。
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公开(公告)号：US10085968B2
公开(公告)日：2018-10-02
申请号：US14950834
申请日：2015-11-24
发明人： Liming Shao , John Emmerson Campbell , Michael Charles Hewitt , Una Campbell , Taleen G. Hanania
IPC分类号： C07D233/00 , C07D403/02 , C07D403/14 , C07D231/00 , C07D487/02 , C07D487/00 , C07D405/00 , C07D409/00 , C07D495/02 , A61K31/415 , A61K31/40 , C07D277/22 , A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
摘要： Provided herein are multicyclic compounds of formula (IVa), shown below, wherein R1, R2, R3, R4, R5, R6, R7, m, and n are defined herein elsewhere, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US10894033B2
公开(公告)日：2021-01-19
申请号：US16791118
申请日：2020-02-14
发明人： Liming Shao , John Emmerson Campbell , Michael Charles Hewitt , Una Campbell , Taleen G. Hanania
IPC分类号： A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , A61K45/06 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , C07D333/78
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US10428021B2
公开(公告)日：2019-10-01
申请号：US15817760
申请日：2017-11-20
IPC分类号： A61K31/4035 , C07D209/44 , C07D209/08 , C07D209/52
摘要： Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.
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公开(公告)号：US09056830B2
公开(公告)日：2015-06-16
申请号：US14078284
申请日：2013-11-12
发明人： Liming Shao , Jianguo Ma
IPC分类号： C07D207/06 , C07D207/08 , C07D405/04 , A61K31/4025 , A61K31/40 , C07D207/12
CPC分类号： C07D207/06 , A61K31/40 , C07D207/08 , C07D207/12 , C07D405/04
摘要： In various embodiments, the present invention provides cycloalkyl pyrrolidine compounds and methods for their use in the treatment and/or prevention of various diseases, conditions and syndromes, including central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
摘要翻译： 在各种实施方案中，本发明提供环烷基吡咯烷化合物及其用于治疗和/或预防各种疾病，病症和综合征的方法，包括中枢神经系统（CNS）障碍，例如抑郁症，焦虑症，精神分裂症和睡眠障碍 以及它们的合成方法。 本发明还涉及含有本发明化合物的药物组合物，以及抑制内源性单胺如从突触间隙中再摄取多巴胺，5-羟色胺和去甲肾上腺素以及调节一种或多种单胺转运蛋白的方法。
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公开(公告)号：US11332462B2
公开(公告)日：2022-05-17
申请号：US16722048
申请日：2019-12-20
IPC分类号： C07D409/04 , C07D409/14 , C07D491/048 , C07D495/04 , C07D405/04
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US09850204B2
公开(公告)日：2017-12-26
申请号：US14850338
申请日：2015-09-10
IPC分类号： A61K31/4035 , C07D209/08 , C07D209/52 , C07D209/44
CPC分类号： C07D209/44 , A61K31/4035 , C07D209/08 , C07D209/52
摘要： Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.
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公开(公告)号：US08754117B2
公开(公告)日：2014-06-17
申请号：US13752086
申请日：2013-01-28
发明人： Liming Shao , Jianguo Ma
IPC分类号： A61K31/4025 , A61K31/40 , C07D207/06 , C07D207/08 , C07D405/04
CPC分类号： C07D207/06 , A61K31/40 , C07D207/08 , C07D207/12 , C07D405/04
摘要： In various embodiments, the present invention provides cycloalkyl pyrrolidine compounds and methods for their use in the treatment and/or prevention of various diseases, conditions and syndromes, including central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
摘要翻译： 在各种实施方案中，本发明提供环烷基吡咯烷化合物及其用于治疗和/或预防各种疾病，病症和综合征的方法，包括中枢神经系统（CNS）障碍，例如抑郁症，焦虑症，精神分裂症和睡眠障碍 以及它们的合成方法。 本发明还涉及含有本发明化合物的药物组合物，以及抑制内源性单胺如从突触间隙中再摄取多巴胺，5-羟色胺和去甲肾上腺素以及调节一种或多种单胺转运蛋白的方法。
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公开(公告)号：US10562878B2
公开(公告)日：2020-02-18
申请号：US15836261
申请日：2017-12-08
发明人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campell
IPC分类号： C07D333/20 , C07C211/17 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07D207/06 , C07D207/08 , C07D211/14 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056 , C07C211/29 , C07D211/16
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
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公开(公告)号：US10189825B2
公开(公告)日：2019-01-29
申请号：US14377673
申请日：2013-02-08
IPC分类号： C07D409/04 , C07D405/04 , C07D495/04 , C07D491/048 , C07D409/14
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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