公开(公告)号：US20190256525A1

公开(公告)日：2019-08-22

申请号：US16277443

申请日：2019-02-15

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Andrea Bauer ,  Nandkumar Nivritti Bhogle ,  Xiaoxia Chen ,  Shahla Jamzad ,  Robert Joseph Prytko ,  Kostas Saranteas ,  Harold Scott Wilkinson ,  Haitao Zhang

IPC: C07D495/04 ,  A61P25/18 ,  A61K9/20

Abstract: Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.

公开(公告)号：US08889685B2

公开(公告)日：2014-11-18

申请号：US13928571

申请日：2013-06-27

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: A61K31/444 ,  A61K31/495 ,  A61K31/4985 ,  C07D213/61 ,  C07D295/182 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D487/04 ,  C07C57/145

Abstract: Maleate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided. The salts are useful for treating sleep disorders.

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b ]吡嗪）。 这些盐可用于治疗睡眠障碍。

公开(公告)号：US20130289040A1

公开(公告)日：2013-10-31

申请号：US13928571

申请日：2013-06-27

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： H. Scott WILKINSON ,  Richard HSIA ,  Tushar MISRA ,  Kostas Saranteas ,  Patrick MOUSAW

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07C57/145

Abstract: A novel maleate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.

公开(公告)号：US20130289039A1

公开(公告)日：2013-10-31

申请号：US13927439

申请日：2013-06-26

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Richard Hsia ,  H. Scott WILKINSON ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: A novel besylate salt of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) is provided.

公开(公告)号：US11440921B2

公开(公告)日：2022-09-13

申请号：US17006101

申请日：2020-08-28

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Andrea Bauer ,  Nandkumar Nivritti Bhogle ,  Xiaoxia Chen ,  Shahla Jamzad ,  Robert Joseph Prytko ,  Kostas Saranteas ,  Michael Joseph Sizensky ,  Harold Scott Wilkinson ,  Haitao Zhang

IPC: C07D495/04 ,  A61K9/20 ,  A61K45/06 ,  A61K31/381 ,  A61P25/18 ,  A61P25/00

Abstract: Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.

公开(公告)号：US08889686B2

公开(公告)日：2014-11-18

申请号：US13932324

申请日：2013-07-01

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： H. Scott Wilkinson ,  Richard Hsia ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: A61K31/44 ,  A61K31/495 ,  A61K31/4985 ,  C07D213/61 ,  C07D295/182 ,  C07D471/04 ,  C07D487/04 ,  C07C59/245

CPC classification number: C07D487/04 ,  C07C59/245

Abstract: L malate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are disclosed for decreasing the bitterness of eszopiclone dosage forms

Abstract translation: （6-（5-氯-2-吡啶基）-5 - [（4-甲基-1-哌嗪基）羰基氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4- b]吡嗪）用于降低右佐佐单抗剂型的苦味

公开(公告)号：US08809332B2

公开(公告)日：2014-08-19

申请号：US13927439

申请日：2013-06-26

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Richard Hsia ,  H. Scott Wilkinson ,  Tushar Misra ,  Kostas Saranteas ,  Patrick Mousaw

IPC: A61K31/444 ,  A61K31/495 ,  A61K31/4985 ,  C07D213/61 ,  C07D295/182 ,  C07D471/04

CPC classification number: C07D487/04

Abstract: Besylate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided.

Abstract translation: -5 - [（4-甲基-1-哌嗪基）羰氧基] -7-氧代-6,7-二氢-5H-吡咯并[3,4-b ]吡嗪）。