公开(公告)号：US20190055204A1

公开(公告)日：2019-02-21

申请号：US16107385

申请日：2018-08-21

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Larry Wendell Hardy ,  Michele L.R. Heffernan ,  Frank Xinhe Wu ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D239/88 ,  C07D487/20 ,  C07D471/20 ,  C07D491/20 ,  C07D413/04 ,  C07D471/04 ,  C07D471/14 ,  C07D487/08 ,  C07D498/04 ,  C07D417/06 ,  C07D487/04 ,  C07D401/14 ,  C07D405/06 ,  C07D403/06

Abstract: Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

公开(公告)号：US20140349992A1

公开(公告)日：2014-11-27

申请号：US14299364

申请日：2014-06-09

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Larry Wendell Hardy ,  Michele L.R. Heffernan ,  Frank Xinhe Wu ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D239/88 ,  C07D405/06 ,  C07D413/04 ,  C07D401/14 ,  C07D471/14 ,  C07D471/20 ,  C07D487/08 ,  C07D498/04 ,  C07D491/20 ,  C07D417/06 ,  C07D487/04

CPC classification number: C07D239/88 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D413/04 ,  C07D417/06 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/04 ,  C07D487/08 ,  C07D487/20 ,  C07D491/20 ,  C07D498/04

Abstract: Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

Abstract translation: 本文提供的化合物及其合成方法。 本文所述的化合物可用于治疗，预防和/或治疗各种疾病，例如神经障碍，神经变性疾病，神经精神障碍，认知障碍，学习或记忆障碍，胃肠道疾病，下尿路障碍和癌症 。 本文所述的化合物调节代谢型谷氨酸受体5（mGluR5）在中枢神经系统或周边的活性。 本文还提供了含有化合物及其使用方法的药物制剂。

公开(公告)号：US20180037585A1

公开(公告)日：2018-02-08

申请号：US15625604

申请日：2017-06-16

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Michele L.R. Heffernan ,  Larry Wendell Hardy ,  Frank Xinhe Wu ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D487/04 ,  C07D498/04 ,  C07D491/22 ,  C07D491/20 ,  C07D491/147 ,  C07D487/18 ,  C07D487/14 ,  C07D471/20 ,  C07D471/14 ,  C07D487/10 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/10 ,  C07D487/14 ,  C07D487/18 ,  C07D491/147 ,  C07D491/20 ,  C07D491/22 ,  C07D498/04

Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.

公开(公告)号：US09708331B2

公开(公告)日：2017-07-18

申请号：US15013741

申请日：2016-02-02

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Michele L. R. Heffernan ,  Larry Wendell Hardy ,  Frank Xinhe Wu ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D487/14 ,  C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/18 ,  C07D491/147 ,  C07D491/20 ,  C07D491/22 ,  C07D498/04 ,  C07D487/10

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/10 ,  C07D487/14 ,  C07D487/18 ,  C07D491/147 ,  C07D491/20 ,  C07D491/22 ,  C07D498/04

Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.

公开(公告)号：US20190135815A1

公开(公告)日：2019-05-09

申请号：US16211338

申请日：2018-12-06

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Michele L.R. Heffernan ,  Larry Wendell Hardy ,  Frank Xinhe Wu ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D487/04 ,  C07D487/10 ,  C07D498/04 ,  C07D491/22 ,  C07D491/20 ,  C07D471/04 ,  C07D487/18 ,  C07D487/14 ,  C07D471/20 ,  C07D471/14 ,  C07D491/147

Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.

公开(公告)号：US10196399B2

公开(公告)日：2019-02-05

申请号：US15625604

申请日：2017-06-16

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Michele L. R. Heffernan ,  Larry Wendell Hardy ,  Frank Xinhe Wu ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/14 ,  C07D487/18 ,  C07D491/147 ,  C07D491/20 ,  C07D491/22 ,  C07D498/04 ,  C07D487/10

Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.

公开(公告)号：US10077243B2

公开(公告)日：2018-09-18

申请号：US14299364

申请日：2014-06-09

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Larry Wendell Hardy ,  Michele L. R. Heffernan ,  Frank Xinhe Wu ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: A61K31/517 ,  C07D487/04 ,  C07D239/88 ,  C07D403/06 ,  C07D405/06 ,  C07D417/06 ,  C07D471/04 ,  C07D487/20 ,  C07D401/14 ,  C07D413/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/08 ,  C07D491/20 ,  C07D498/04

CPC classification number: C07D239/88 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D413/04 ,  C07D417/06 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/04 ,  C07D487/08 ,  C07D487/20 ,  C07D491/20 ,  C07D498/04

Abstract: Provided herein are compounds of formula (I): and pharmaceutical compositions thereof, useful for the treatment of disorders mediated by metabotropic glutamate receptor 5.

公开(公告)号：US20200079778A9

公开(公告)日：2020-03-12

申请号：US16211338

申请日：2018-12-06

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Michele L.R. Heffernan ,  Larry Wendell Hardy ,  Frank Xinhe Wu ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D487/04 ,  C07D487/10 ,  C07D498/04 ,  C07D491/22 ,  C07D491/20 ,  C07D471/04 ,  C07D487/18 ,  C07D487/14 ,  C07D471/20 ,  C07D471/14 ,  C07D491/147

Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.

公开(公告)号：US20160251359A1

公开(公告)日：2016-09-01

申请号：US15013741

申请日：2016-02-02

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Michele L.R. Heffernan ,  Larry Wendell Hardy ,  Frank Xinhe WU ,  Lakshmi D. Saraswat ,  Kerry L. Spear

IPC: C07D487/04 ,  C07D487/14 ,  C07D491/147 ,  C07D491/22 ,  C07D487/18 ,  C07D491/20 ,  C07D471/14 ,  C07D487/10

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D487/10 ,  C07D487/14 ,  C07D487/18 ,  C07D491/147 ,  C07D491/20 ,  C07D491/22 ,  C07D498/04

Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.

Abstract translation: 公开了调节GluR5活性的化合物及其使用方法。