公开(公告)号：US20240108559A1

公开(公告)日：2024-04-04

申请号：US18533176

申请日：2023-12-08

Applicant: ELC MANAGEMENT LLC ,  SYMRISE AG

Inventor： Nadine PERNODET ,  Chia-Wen CHEN ,  Kelly DONG ,  Jingyu HUANG ,  Oskar KOCH ,  Nikolas BUGDAHN

IPC: A61K8/37 ,  A61K8/06 ,  A61Q17/04 ,  A61Q19/08

CPC classification number: A61K8/37 ,  A61K8/064 ,  A61Q17/04 ,  A61Q19/08 ,  A61K2800/522

Abstract: The present invention relates to a method for synthesizing sinapoyl malate comprising the steps of (a) (i) reacting syringaldehyde with acetic acid anhydride and an alkali metal acetate; or (ii) reacting sinapinic acid with acetic acid anhydride, and (b) cleaving the anhydride of the acetyl protected reaction product of (a) by exposing to water and an aliphatic alcohol to form protected sinapinic acid, (c) esterifyinig the protected sinapinic acid by reacting with an alkyl protected carboxylic acid ester to form protected sinapoyl malate, and (d) reacting the protected sinapoyl malate with aqueous acid to yield sinapoyl malate.

公开(公告)号：US20180244642A1

公开(公告)日：2018-08-30

申请号：US15553638

申请日：2016-02-26

Applicant: SYMRISE AG

Inventor： Oskar KOCH ,  Marcus Rudolf GÖTZ

IPC: C07D311/80 ,  C07C69/94

CPC classification number: C07D311/80 ,  A61K31/235 ,  A61K31/352 ,  A61K2300/00 ,  C07C37/50 ,  C07C39/23 ,  C07C67/03 ,  C07C67/343 ,  C07C69/94 ,  C07C2601/14 ,  C07C2601/16

Abstract: Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for their production. Further described are a compound of the formula (A), a salt of the formula (A) and a corresponding mixture for use as a medicament or, respectively, for use in a method for therapeutic treatment of the human or animal body.Described are also corresponding pharmaceutical formulations, cosmetic preparations and preparations for pleasure and/or nutrition, suitable for consumption, as well as methods for producing CBDV and THCV.

公开(公告)号：US20210253509A1

公开(公告)日：2021-08-19

申请号：US17255590

申请日：2018-06-28

Applicant: SYMRISE AG

Inventor： Bernd FIEBICH ,  Matthias WINKLER ,  Marcus Rudolf GÖTZ ,  Oskar KOCH

IPC: C07C67/02 ,  C07C67/32 ,  C07C37/50

Abstract: The present invention relates to a method of producing a compound of formula (I) or a salt of a compound of formula (I). The invention also relates to a compound of formula (I) or a salt of a compound of formula (I) for use in a therapeutic method to achieve one or more therapeutic effects as well as for use in the treatment and/or prevention of certain diseases. Furthermore, the invention provides a pharmaceutical composition comprising one or more compound(s) of formula (I) or salt(s) of compound(s) of formula (I).

公开(公告)号：US20190077783A1

公开(公告)日：2019-03-14

申请号：US16181503

申请日：2018-11-06

Applicant: SYMRISE AG

Inventor： Oskar KOCH ,  Marcus Rudolf GÖTZ

IPC: C07D311/80 ,  C07C37/50 ,  C07C69/94 ,  A61K31/235 ,  A61K31/352 ,  C07C39/23 ,  C07C67/03 ,  C07C67/343

Abstract: Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for their production. Further described are a compound of the formula (A), a salt of the formula (A) and a corresponding mixture for use as a medicament or, respectively, for use in a method for therapeutic treatment of the human or animal body.Described are also corresponding pharmaceutical formulations, cosmetic preparations and preparations for pleasure and/or nutrition, suitable for consumption, as well as methods for producing CBDV and THCV.

公开(公告)号：US20210107885A1

公开(公告)日：2021-04-15

申请号：US17113248

申请日：2020-12-07

Applicant: SYMRISE AG

Inventor： Oskar KOCH ,  Marcus Rudolf GÖTZ

IPC: C07D311/80 ,  A61K31/235 ,  A61K31/352 ,  C07C69/94 ,  C07C67/03 ,  C07C67/343 ,  C07C37/50 ,  C07C39/23

Abstract: Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for their production. Further described are a compound of the formula (A), a salt of the formula (A) and a corresponding mixture for use as a medicament or, respectively, for use in a method for therapeutic treatment of the human or animal body.
Described are also corresponding pharmaceutical formulations, cosmetic preparations and preparations for pleasure and/or nutrition, suitable for consumption, as well as methods for producing CBDV and THCV.

公开(公告)号：US20180022683A1

公开(公告)日：2018-01-25

申请号：US15547435

申请日：2016-01-13

Applicant: SYMRISE AG

Inventor： Atia HANAN ,  Reinhard ECKELT ,  Angela KOECKRITZ ,  Johannes PANTEN ,  Peter ESSER ,  Oskar KOCH

IPC: C07C67/293 ,  C07C69/12

CPC classification number: C07C67/293 ,  C07C45/69 ,  C07C49/497 ,  C07C49/503 ,  C07C51/353 ,  C07C68/00 ,  C07C69/12 ,  C07C303/24 ,  C07C2601/18 ,  C07C2601/20 ,  C07F9/091 ,  Y02P20/582 ,  C07C69/14 ,  C07C69/96

Abstract: The present invention relates to a method for producing a substituted alkyl cycloalkanone of formula (I), having the alkylation of a cycloalkanone of formula (II) with an alkene derivative of formula (III) in the presence of a metal oxide, where n is 2 to 20, m is 0 to 10, and R is a functional group.

公开(公告)号：US20210137805A1

公开(公告)日：2021-05-13

申请号：US16491570

申请日：2018-03-06

Applicant: ELC MANAGEMENT LLC ,  Symrise AG

Inventor： Nadine PERNODET ,  Chia-Wen CHEN ,  Kelly DONG ,  Jingyu HUANG ,  Oskar KOCH ,  Nikolas BUGDAHN

IPC: A61K8/37 ,  A61Q19/08 ,  A61Q17/04 ,  A61K8/06

Abstract: A topical composition comprising a synthetic compound that is an ester of sinapinic acid, a method for treating skin to provide one or more benefits selected from (a) protecting against UV radiation, (b) inhibiting DNA damage in skin cells, (c) inhibiting skin inflammation, and (d) scavenging free radicals by topically applying a composition containing the synthetic compound and a method for synthesizing the compound.