公开(公告)号：US11136289B2

公开(公告)日：2021-10-05

申请号：US16884231

申请日：2020-05-27

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Martin Zeller ,  Nicolas Fedou

IPC: C07C255/35 ,  C07C51/08 ,  C07C53/134 ,  C07C255/33 ,  C07C253/30 ,  B01J31/24

Abstract: Process for the preparation of a compound of Formula (I): the process comprising the reaction of a compound of Formula (II) with malononitrile in the presence of a base and a palladium catalyst, wherein X, Y and Z, independently of each other, represent fluoro, chloro or C1-4alkyl; and L is a leaving group; with the proviso that 1 or 2 of X and Y are, independently of each other, fluoro or chloro.

公开(公告)号：US09051272B2

公开(公告)日：2015-06-09

申请号：US14374547

申请日：2013-02-26

Applicant: Syngenta Participations AG

Inventor： Daniel Stierli ,  Harald Walter ,  Michael Rommel ,  Reinhard Georg Hanreich ,  Martin Zeller ,  Thomas Vettiger ,  Tomas Smejkal

IPC: C07D231/12 ,  C07D231/14

CPC classification number: C07D231/12 ,  C07D231/14

Abstract: The invention relates to a process for the preparation of a compound of formula (I), wherein R1, R2 and R3 are as defined in claim 1, which process comprises a) adding a compound of formula (II), in the presence of an inert organic solvent to a mixture comprising an organic nitrite of formula (III) (R4—O—N═O (III)), wherein R4 is C1-C8alkyl, a compound of formula (IV), and an inert organic solvent; b) reacting the resulting compound of formula (V), with H2N—O—CH3 to the compound of formula (VII), c) reducing the compound of formula (VII) to the compound of formula (VIII), d) and reacting the compound of formula VIII with a compound of formula (IX), in which R* is halogen, hydroxy or C1-6 alkoxy, to the compound of formula (I).

Abstract translation: 本发明涉及一种制备式（I）化合物的方法，其中R 1，R 2和R 3如权利要求1所定义，该方法包括：a）将式（II）化合物在 惰性有机溶剂与含有式（III）有机亚硝酸酯（R4-O-N = O（Ⅲ））的混合物，其中R4为C1-C8烷基，式（Ⅳ）化合物和惰性有机溶剂; b）将得到的式（Ⅴ）化合物与H 2 N-O-CH 3反应于式（Ⅶ）化合物，c）将式（Ⅶ）化合物还原为式（Ⅷ）化合物，d） 式Ⅸ化合物与式（Ⅸ）化合物反应，其中R *为卤素，羟基或C 1-6烷氧基。

公开(公告)号：US20200283374A1

公开(公告)日：2020-09-10

申请号：US16884231

申请日：2020-05-27

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Martin Zeller ,  Nicolas Fedou

IPC: C07C255/35 ,  C07C51/08 ,  C07C53/134 ,  C07C255/33 ,  C07C253/30

Abstract: Process for the preparation of a compound of Formula (I): the process comprising the reaction of a compound of Formula (II) with malononitrile in the presence of a base and a palladium catalyst, wherein X, Y and Z, independently of each other, represent fluoro, chloro or C1-4alkyl; and L is a leaving group; with the proviso that 1 or 2 of X and Y are, independently of each other, fluoro or chloro.

公开(公告)号：US10759742B2

公开(公告)日：2020-09-01

申请号：US16319304

申请日：2017-07-20

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Martin Zeller ,  Nicolas Fedou

IPC: C07C255/35 ,  C07C51/08 ,  C07C53/134 ,  C07C255/33 ,  C07C253/30 ,  B01J31/24

Abstract: Process for the preparation of a compound of Formula (I), the process comprising the reaction of a compound of Formula (II) with malononitrile in the presence of a base and a palladium catalyst, Formula (II) wherein X, Y and Z, independently of each other, represent fluoro, chloro or C1-4alkyl; and L is a leaving group; with the proviso that 1 or 2 of X and Y are, independently of each other, fluoro or chloro.

公开(公告)号：US20150018562A1

公开(公告)日：2015-01-15

申请号：US14374547

申请日：2013-02-26

Applicant: Syngenta Participations AG

Inventor： Daniel Stierli ,  Harald Walter ,  Michael Rommel ,  Reinhard Georg Hanreich ,  Martin Zeller ,  Thomas Vettiger ,  Tomas Smejkal

IPC: C07D231/12

CPC classification number: C07D231/12 ,  C07D231/14

Abstract: The invention relates to a process for the preparation of a compound of formula (I), wherein R1, R2 and R3 are as defined in claim 1, which process comprises a) adding a compound of formula (II), in the presence of an inert organic solvent to a mixture comprising an organic nitrite of formula (III) (R4—O—N═O (III)), wherein R4 is C1-C8 alkyl, a compound of formula (IV), and an inert organic solvent; b) reacting the resulting compound of formula (V), with H2N—O—CH3 to the compound of formula (VII), c) reducing the compound of formula (VII) to the compound of formula (VIII), d) and reacting the compound of formula VIII with a compound of formula (IX), in which R* is halogen, hydroxy or C1-6 alkoxy, to the compound of formula (I).

Abstract translation: 本发明涉及一种制备式（I）化合物的方法，其中R 1，R 2和R 3如权利要求1所定义，该方法包括：a）将式（II）化合物在 惰性有机溶剂加入到包含式（III）的有机亚硝酸酯（R4-O-N = O（III））的混合物中，其中R4是C1-C8烷基，式（IV）化合物和惰性有机溶剂; b）将得到的式（Ⅴ）化合物与H 2 N-O-CH 3反应于式（Ⅶ）化合物，c）将式（Ⅶ）化合物还原为式（Ⅷ）化合物，d） 式Ⅸ化合物与式（Ⅸ）化合物反应，其中R *为卤素，羟基或C 1-6烷氧基。