公开(公告)号：US20230258545A1

公开(公告)日：2023-08-17

申请号：US18309161

申请日：2023-04-28

申请人： SYSMEX CORPORATION

发明人： Hiroaki INOKUCHI ,  Toshikuni SUGANUMA ,  Kei SHIRASUNA

IPC分类号： G01N1/38 ,  G01N33/483

CPC分类号： G01N1/38 ,  G01N33/4833 ,  G01N35/1009

摘要： Automation of analysis of cells contained in different types of specimens collected from different organs or sites is enabled. This sample preparation method is a method for preparing a sample for analyzing cells contained in a specimen, and includes: obtaining a dispersion condition corresponding to the type of the specimen; and dispersing the cells aggregated and contained in the specimen, according to the obtained dispersion condition.

公开(公告)号：US20230273609A1

公开(公告)日：2023-08-31

申请号：US18172113

申请日：2023-02-21

申请人： Sysmex Corporation

发明人： Kei SHIRASUNA ,  Daigo Fukuma ,  Yuto Nagao ,  Fumiaki Hayashi ,  Kanako Kiso ,  Tomomi Kohno

IPC分类号： G05B19/418

CPC分类号： G05B19/41875 ,  G05B2219/32368

摘要： Disclosed is a method for applying a control reference value regarding a quality control sample to a specimen analyzer by a computer, the method comprising: generating the control reference value on the basis of a measurement result of the quality control sample measured by the specimen analyzer; and applying the control reference value to the specimen analyzer.

公开(公告)号：US20200096433A1

公开(公告)日：2020-03-26

申请号：US16694058

申请日：2019-11-25

申请人： Sysmex Corporation

发明人： Kei SHIRASUNA ,  Ryuichiro EBI ,  Shigeki ABE

IPC分类号： G01N15/14 ,  C12Q1/6886 ,  G16B30/00 ,  G01N21/49

摘要： Disclosed is a cell analysis method comprising: extracting target cells from a population of cells derived from an epithelial tissue on the basis of N/C ratio representing a relative size of a nucleus to a cytoplasm; classifying the target cells into at least a first group and a second group by difference of amount of DNA; and evaluating a pathology of the epithelial tissue by comparing a ratio of numbers of cells between the first and second groups with a threshold; wherein the threshold varies according to a proportion of the target cells in the population.

公开(公告)号：US20190086317A1

公开(公告)日：2019-03-21

申请号：US16134175

申请日：2018-09-18

申请人： SYSMEX CORPORATION

发明人： Hiroaki INOKUCHI ,  Kei SHIRASUNA

IPC分类号： G01N15/02 ,  G01N15/14 ,  G06F19/28 ,  G06F19/24

摘要： The method includes a counting step of counting, among cells included in a sample, a first cell number indicating the number of cells classified into a first group based on cell size and cell nucleus size and having a DNA amount greater than a threshold value, and a second cell number indicating the number of cells classified into a second group that is different from the first group based on the cell size and cell nucleus size and having a DNA amount greater than the threshold value; and a comparing step of comparing the first cell number with the second cell number.

公开(公告)号：US20150104786A1

公开(公告)日：2015-04-16

申请号：US14508522

申请日：2014-10-07

申请人： Sysmex Corporation

发明人： Kei SHIRASUNA ,  Ryuichiro EBI ,  Shigeki ABE

IPC分类号： G01N15/14 ,  G06F19/22 ,  G01N21/49

CPC分类号： G01N15/147 ,  C12Q1/6886 ,  G01N15/1431 ,  G01N21/49 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1477 ,  G16B30/00

摘要： Disclosed is a cell analysis method comprising: extracting target cells from a population of cells derived from an epithelial tissue on the basis of N/C ratio representing a relative size of a nucleus to a cytoplasm; classifying the target cells into at least a first group and a second group by difference of amount of DNA; and evaluating a pathology of the epithelial tissue by comparing a ratio of numbers of cells between the first and second groups with a threshold; wherein the threshold varies according to a proportion of the target cells in the population.

摘要翻译： 公开了一种细胞分析方法，其包括：基于代表细胞核的相对大小与细胞质的N / C比率从源自上皮组织的细胞群中提取靶细胞; 通过DNA量的差异将靶细胞分类为至少第一组和第二组; 以及通过将所述第一组和第二组之间的细胞数比率与阈值进行比较来评估所述上皮组织的病理学; 其中所述阈值根据所述群体中的所述靶细胞的比例而变化。