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1.发明公开公开(公告)号：US20240118272A1
公开(公告)日：2024-04-11
申请号：US18469093
申请日：2023-09-18
Applicant: SYSMEX CORPORATION
Inventor： Eiya TAMADA , Masatoshi Yanagida , Kazuto Yamashita , Elnaz Nakhael , Mami Onishi , Maria Kiriyama
IPC: G01N33/543 , C07K14/705 , C07K16/28
CPC classification number: G01N33/54333 , C07K14/70596 , C07K16/2803 , C07K16/2896 , G01N2333/916 , G01N2496/00
Abstract: Disclosed is a method for measuring an activity of alkaline phosphatase contained in an extracellular vesicle in a sample, including acquiring an activity value of alkaline phosphatase contained in an extracellular vesicle in a sample using a calibrator, in which the calibrator contains a conjugate in which a polypeptide having alkaline phosphatase activity and a polypeptide including an amino acid sequence of a membrane protein present on a surface of the extracellular vesicle are covalently bound.
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公开(公告)号：US11486875B2
公开(公告)日：2022-11-01
申请号：US17023946
申请日：2020-09-17
Applicant: SYSMEX CORPORATION
Inventor： Keiko Yoshikawa , Amane Harada , Katsuhiro Murakami , Maria Kiriyama , Keiko Miwa , Takuya Kubo
Abstract: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.
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公开(公告)号：US10436806B2
公开(公告)日：2019-10-08
申请号：US14882812
申请日：2015-10-14
Applicant: SYSMEX CORPORATION
Inventor： Amane Harada , Katsuhiro Murakami , Maria Kiriyama , Keiko Yoshikawa , Keiko Miwa
Abstract: Provided is a method of measuring a lipoprotein's capacity to accept cholesterol including the steps of bringing a lipoprotein in a sample into contact with labeled cholesterol to incorporate the labeled cholesterol into the lipoprotein, bringing the lipoprotein having the labeled cholesterol into contact with an antibody that binds to a lipoprotein to form a complex of the lipoprotein and the antibody, and measuring the label incorporated into the complex.
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公开(公告)号：US10809249B2
公开(公告)日：2020-10-20
申请号：US15650414
申请日：2017-07-14
Applicant: SYSMEX CORPORATION
Inventor： Keiko Yoshikawa , Amane Harada , Katsuhiro Murakami , Maria Kiriyama , Keiko Miwa , Takuya Kubo
Abstract: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.
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