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公开(公告)号：US11486875B2
公开(公告)日：2022-11-01
申请号：US17023946
申请日：2020-09-17
Applicant: SYSMEX CORPORATION
Inventor： Keiko Yoshikawa , Amane Harada , Katsuhiro Murakami , Maria Kiriyama , Keiko Miwa , Takuya Kubo
Abstract: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.
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公开(公告)号：US10676784B2
公开(公告)日：2020-06-09
申请号：US15075358
申请日：2016-03-21
Applicant: SYSMEX CORPORATION
Inventor： Takuya Kubo , Shigeki Iwanaga
IPC: G01N21/64 , C12Q1/6841 , G02B21/00
Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.
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Patent Agency Ranking
公开(公告)号：US10809249B2
公开(公告)日：2020-10-20
申请号：US15650414
申请日：2017-07-14
Applicant: SYSMEX CORPORATION
Inventor： Keiko Yoshikawa , Amane Harada , Katsuhiro Murakami , Maria Kiriyama , Keiko Miwa , Takuya Kubo
Abstract: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.
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公开(公告)号：US20230242499A1
公开(公告)日：2023-08-03
申请号：US18158006
申请日：2023-01-23
Applicant: SYSMEX CORPORATION
Inventor： Shinnosuke UNO , Takuya Kubo
IPC: C07D315/00 , C07F9/09 , C07F5/02 , C07D407/12
CPC classification number: C07D315/00 , C07F9/091 , C07F5/027 , C07D407/12
Abstract: Disclosed is a compound represented by formula [I] according to the specification, or a salt thereof, a composition comprising the compound, a chemiluminescence method using the compound, a method for measuring chemiluminescence signal, a reagent comprising the compound, a reagent kit comprising the compound and a method for assaying analyte.
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公开(公告)号：US11473130B2
公开(公告)日：2022-10-18
申请号：US16658190
申请日：2019-10-21
Applicant: SYSMEX CORPORATION
Inventor： Takuya Kubo , Shigeki Iwanaga
IPC: G01N21/64 , G01N1/44 , C12Q1/6841 , G02B21/00
Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.
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公开(公告)号：US10604731B2
公开(公告)日：2020-03-31
申请号：US15695633
申请日：2017-09-05
Applicant: Sysmex Corporation
Inventor： Kanako Masumoto , Takuya Kubo , Shigeki Iwanaga , Masaya Okada
Abstract: Provided is a cell analyzer including: a light source unit configured to apply light to test cells each containing first substances which are bound to first fluorescent dyes and which serve as an index for therapeutic strategy judgement; an image capturing unit configured to capture an image of fluorescence caused by the light; a processing unit configured to process the image obtained by the image capturing unit; and a display unit configured to display a process result obtained by the processing unit, wherein the processing unit obtains a first image by performing an inactivation process of quenching the first fluorescent dyes, an activation process of activating a part of the first fluorescent dyes that have been quenched, and an image capturing process of capturing, by means of the image capturing unit, an image of the fluorescence by applying light from the light source unit to each test cell; extracts bright points based on the first fluorescent dyes on the basis of the first image; classifies the extracted bright points into groups each corresponding to one first substance, thereby to obtain the number of the first substances in the test cell on the basis of the number of the classified groups; obtains therapy index information serving as an index for therapeutic strategy judgement, on the basis of the obtained number of the first substances; and causes the display unit to display the obtained therapy index information.
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公开(公告)号：US10533217B2
公开(公告)日：2020-01-14
申请号：US15075358
申请日：2016-03-21
Applicant: SYSMEX CORPORATION
Inventor： Takuya Kubo , Shigeki Iwanaga
IPC: G01N21/64 , C12Q1/6841 , G02B21/00
Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.
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