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公开(公告)号：US06462034B1
公开(公告)日：2002-10-08
申请号：US09411331
申请日：1999-10-01
申请人： Sabine M. Axt , Timothy J. Church , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice , Huiwei Wu , Witold Hruzewicz
发明人： Sabine M. Axt , Timothy J. Church , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice , Huiwei Wu , Witold Hruzewicz
IPC分类号： A61K4372
CPC分类号： C07C237/04 , C07C237/34 , C07D211/60 , C07D273/00
摘要： Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
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公开(公告)号：US06337423B1
公开(公告)日：2002-01-08
申请号：US09285054
申请日：1999-04-02
申请人： Sabine M. Axt , Timothy J. Church , Witold Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
发明人： Sabine M. Axt , Timothy J. Church , Witold Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
IPC分类号： C07C23305
CPC分类号： C07C237/34 , C07C237/04 , C07D211/60 , C07D273/00
摘要： Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
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公开(公告)号：US06495681B1
公开(公告)日：2002-12-17
申请号：US09690019
申请日：2000-10-17
申请人： Sabine M. Axt , Timothy J. Church , Witold Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
发明人： Sabine M. Axt , Timothy J. Church , Witold Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
IPC分类号： C07D27308
CPC分类号： C07C237/34 , C07C237/04 , C07D211/60 , C07D273/00
摘要： Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
摘要翻译： 公开了新的化合物，药物组合物和方法用于产生长时间的局部麻醉。 本发明的化合物是包含共价连接到连接体或连接体的2至10个配体的多结合化合物，每个配体能够结合电压门控Na +通道中的配体结合位点以调节其生物学过程/功能。
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公开(公告)号：US06576791B1
公开(公告)日：2003-06-10
申请号：US09647802
申请日：2000-10-03
申请人： Sabine M. Axt , Timothy J. Church , Witold N. Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
发明人： Sabine M. Axt , Timothy J. Church , Witold N. Hruzewicz , John R. Jacobsen , Thomas E. Jenkins , Yu-Hua Ji , J. Kevin Judice
IPC分类号： C07C23305
CPC分类号： C07C237/34 , C07C237/04 , C07D211/60 , C07D273/00
摘要： Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
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公开(公告)号：US06518242B1
公开(公告)日：2003-02-11
申请号：US09253670
申请日：1999-02-19
申请人： Qi-Qi Chen , John H. Griffin , Thomas E. Jenkins , J. Kevin Judice , Martin S. Linsell , Michael R. Leadbetter
发明人： Qi-Qi Chen , John H. Griffin , Thomas E. Jenkins , J. Kevin Judice , Martin S. Linsell , Michael R. Leadbetter
IPC分类号： A61K3812
摘要： Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to a transglycosylase enzyme substrate thereby modulating the biological processes/functions thereof.
摘要翻译： 公开了作为多结合剂的新型抗菌剂。 本发明的化合物包含共价连接的2-10个配体，每个所述配体能够结合转糖基酶底物，从而调节其生物学过程/功能。
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6.发明授权公开(公告)号：US07723470B2
公开(公告)日：2010-05-25
申请号：US11977377
申请日：2007-10-24
申请人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
发明人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
IPC分类号： C07K7/50
摘要： Disclosed are compounds of the formula: or a trifluoroacetic acid salt thereof, wherein A, B and Fmoc are as defined herein. Such compounds are useful as synthetic intermediates for preparing glycopeptides antibiotics.
摘要翻译： 公开了下式的化合物或其三氟乙酸盐，其中A，B和Fmoc如本文所定义。 这些化合物可用作制备糖肽抗生素的合成中间体。
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公开(公告)号：US07026288B2
公开(公告)日：2006-04-11
申请号：US10930585
申请日：2004-08-31
申请人： J. Kevin Judice , Jeng Pyng Shaw , YongQi Mu , Michael W. Conner , John L. Pace
发明人： J. Kevin Judice , Jeng Pyng Shaw , YongQi Mu , Michael W. Conner , John L. Pace
IPC分类号： A61K31/715 , C07K14/00
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/02 , A61K9/19 , A61K9/2018 , A61K9/4858 , A61K31/724 , A61K38/14 , A61K47/06 , A61K47/12 , A61K47/26 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
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8.发明授权Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin 有权含有糖肽抗生素和环糊精的药物组合物公开(公告)号：US08158580B2
公开(公告)日：2012-04-17
申请号：US12431940
申请日：2009-04-29
申请人： J. Kevin Judice , Jeng-Pyng Shaw , YongQi Mu , Michael W. Conner , John L. Pace
发明人： J. Kevin Judice , Jeng-Pyng Shaw , YongQi Mu , Michael W. Conner , John L. Pace
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/02 , A61K9/19 , A61K9/2018 , A61K9/4858 , A61K31/724 , A61K38/14 , A61K47/06 , A61K47/12 , A61K47/26 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
摘要翻译： 公开了含有环糊精和治疗有效量的糖肽抗生素或其盐的药物组合物。 还公开了通过施用这种药物组合物治疗哺乳动物细菌性疾病的方法。
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公开(公告)号：US07157554B2
公开(公告)日：2007-01-02
申请号：US11080130
申请日：2005-03-15
IPC分类号： C07K9/00
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译： 公开了在C-末端和/或R末端被包含一个或多个糖基和羧基的取代基取代的糖肽衍生物; 和含有这些糖肽衍生物的药物组合物。 所公开的糖肽衍生物可用作抗菌剂。
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10.发明授权Pharmaceutical compositions containing a gycopeptide antibiotic and a cyclodextrin 有权含有糖肽抗生素和环糊精的药物组合物公开(公告)号：US07067483B2
公开(公告)日：2006-06-27
申请号：US10931122
申请日：2004-08-31
申请人： J. Kevin Judice , Jeng Pyng Shaw , YongQi Mu , Michael W. Conner , John L. Pace
发明人： J. Kevin Judice , Jeng Pyng Shaw , YongQi Mu , Michael W. Conner , John L. Pace
IPC分类号： A61K38/14 , A61K38/10 , A61K31/715
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/02 , A61K9/19 , A61K9/2018 , A61K9/4858 , A61K31/724 , A61K38/14 , A61K47/06 , A61K47/12 , A61K47/26 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are pharmaceutical composition containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering said pharmaceutical composition.
摘要翻译： 公开了含有环糊精和治疗有效量的糖肽抗生素或其盐的药物组合物。 还公开了通过施用所述药物组合物来治疗哺乳动物细菌性疾病的方法。
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