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    USE OF NITROANILINE DERIVATIVES FOR THE PRODUCTION OF NITRIC OXIDE
    1.
    发明申请
    USE OF NITROANILINE DERIVATIVES FOR THE PRODUCTION OF NITRIC OXIDE 有权
    使用硝基苯胺衍生物生产氮氧化物

    公开(公告)号：US20090191284A1

    公开(公告)日：2009-07-30

    申请号：US12360004

    申请日：2009-01-26

    申请人： Sabrina Conoci ,  Salvatore Petralia ,  Salvatore Sortino

    发明人： Sabrina Conoci ,  Salvatore Petralia ,  Salvatore Sortino

    IPC分类号： A61K33/00 ,  C07F15/00 ,  G03C1/73 ,  C01B21/24 ,  B01J19/12

    CPC分类号： C07C211/52 ,  A61K31/04 ,  A61K33/00 ,  B01J19/123 ,  B01J2219/089 ,  C01B21/24 ,  C07C323/29 ,  A61K2300/00

    摘要： The present disclosure relates to the use of a nitroaniline derivative of Formula (I) for the production of nitric oxide and for the preparation of a medicament for the treatment of a disease wherein the administration of nitric oxide is beneficial. The present disclosure furthermore relates to a method for the production of NO irradiating a nitroaniline derivative of Formula (I), a kit comprising a nitroaniline derivative of Formula (I) and a carrier and to a system comprising a source of radiations and a container associated to a nitroaniline derivative of Formula (I). In Formula (I), R and RI are each independently hydrogen or a C1-C3 alkyl group; RII is hydrogen or an alkyl group.

    摘要翻译： 本公开涉及式（I）的硝基苯胺衍生物在制备一氧化氮中的用途，以及制备用于治疗一氧化氮是有益的疾病的药物的用途。 本公开还涉及一种制备式（I）的硝基苯胺衍生物的NO的制备方法，包括式（I）的硝基苯胺衍生物和载体的试剂盒和包含辐射源和容器相关联的体系的试剂盒 涉及式（I）的硝基苯胺衍生物。 在式（I）中，R和R 1各自独立地为氢或C 1 -C 3烷基; RII是氢或烷基。

    Use of nitroaniline derivatives for the production of nitric oxide
    2.
    发明授权
    Use of nitroaniline derivatives for the production of nitric oxide 有权
    使用硝基苯胺衍生物生产一氧化氮

    公开(公告)号：US08440849B2

    公开(公告)日：2013-05-14

    申请号：US12360004

    申请日：2009-01-26

    申请人： Sabrina Conoci ,  Salvatore Petralia ,  Salvatore Sortino

    发明人： Sabrina Conoci ,  Salvatore Petralia ,  Salvatore Sortino

    IPC分类号： C07C17/02 ,  C07C211/00

    CPC分类号： C07C211/52 ,  A61K31/04 ,  A61K33/00 ,  B01J19/123 ,  B01J2219/089 ,  C01B21/24 ,  C07C323/29 ,  A61K2300/00

    摘要： The present disclosure relates to the use of a nitroaniline derivative of Formula (I) for the production of nitric oxide and for the preparation of a medicament for the treatment of a disease wherein the administration of nitric oxide is beneficial. The present disclosure furthermore relates to a method for the production of NO irradiating a nitroaniline derivative of Formula (I), a kit comprising a nitroaniline derivative of Formula (I) and a carrier and to a system comprising a source of radiations and a container associated to a nitroaniline derivative of Formula (I). In Formula (I), R and RI are each independently hydrogen or a C1-C3 alkyl group; RII is hydrogen or an alkyl group.

    摘要翻译： 本公开涉及式（I）的硝基苯胺衍生物在制备一氧化氮中的用途，以及制备用于治疗一氧化氮是有益的疾病的药物的用途。 本公开还涉及一种制备式（I）的硝基苯胺衍生物的NO的制备方法，包括式（I）的硝基苯胺衍生物和载体的试剂盒和包含辐射源和容器相关联的体系的试剂盒 与式（I）的硝基苯胺衍生物反应。 在式（I）中，R和R 1各自独立地为氢或C 1 -C 3烷基; RII是氢或烷基。

    Method and system for producing optically transparent noble metal films
    4.
    发明授权
    Method and system for producing optically transparent noble metal films 有权
    用于制造光学透明贵金属膜的方法和系统

    公开(公告)号：US07902070B2

    公开(公告)日：2011-03-08

    申请号：US11415843

    申请日：2006-05-01

    申请人： Sabrina Conoci ,  Salvatore Petralia

    发明人： Sabrina Conoci ,  Salvatore Petralia

    IPC分类号： H01L21/44 ,  H01L21/302

    CPC分类号： C23C14/185

    摘要： A method and system for producing a noble metal film includes the step of sputtering a noble metal on a substrate thus obtaining a film. The method and system further includes the step of subjecting the film to a thermal treatment, thus obtaining the noble metal film.

    摘要翻译： 制造贵金属膜的方法和系统包括在基板上溅射贵金属从而获得膜的步骤。 该方法和系统还包括对薄膜进行热处理的步骤，从而获得贵金属薄膜。

    Bifunctional chemical, preparation and use for detecting nucleic acid
    5.
    发明授权
    Bifunctional chemical, preparation and use for detecting nucleic acid 有权
    双功能化学，制备和用于检测核酸

    公开(公告)号：US07799912B2

    公开(公告)日：2010-09-21

    申请号：US11875755

    申请日：2007-10-19

    申请人： Sabrina Conoci ,  Salvatore Sortino

    发明人： Sabrina Conoci ,  Salvatore Sortino

    IPC分类号： C07D279/00 ,  C12Q1/68 ,  G01N15/06 ,  C07H21/04

    CPC分类号： C07D213/30

    摘要： A bifunctional compound comprising a molecular unit (I) intercalating between nucleobases (B) of nucleic acids, an active molecular unit (AD) capable of emitting a detectable signal, and optionally a spacer unit, in which the active molecular unit (AD) is selected from amongst chemical entities having a structure such as to interact electronically with the intercalating molecular unit (I) in such a way that, during the reaction of oxidation, the reduction-oxidation potential (EI+/I) of the semicouple I+/I defined by the intercalating molecular unit (I) is lower than the reduction-oxidation potential (EB+/B) of the semicouple B+/B defined by the nucleobases (B), and in such a way that, during the reaction of reduction, the reduction-oxidation potential (EI/I−) of the semicouple I/I− defined by the intercalating molecular unit (I) is higher than the reduction-oxidation potential (EB/B−) of the semicouple B/B− defined by the nucleobases (B). Moreover the use of the compound for detecting nucleic acids, a process for its synthesis, and a system comprising the same are described.

    摘要翻译： 包含嵌入核酸碱基（B）之间的分子单元（I），能够发射可检测信号的活性分子单元（AD）和任选的间隔单元的双功能化合物，其中活性分子单元（AD）为 选自具有如下结构的化学实体，其结构使得与插层分子单元（I）以电子方式相互作用，使得在氧化反应期间，所述半导体I + / I的还原氧化电位（EI + / I）被定义 插层分子单元（I）的含量低于由核碱基（B）定义的半组分B + / B的还原 - 氧化电位（EB + / B），并且在还原反应期间还原 由插入分子单元（I）定义的半配偶I / I的氧化电位（EI / I）高于由核碱基限定的半组分B / B-的还原 - 氧化电位（EB / B-） （B）。 此外，描述了化合物用于检测核酸的用途，其合成方法和包含其的体系。

    Bifunctional Chemical, Preparation and Use for Detecting Nucleic Acid
    6.
    发明申请
    Bifunctional Chemical, Preparation and Use for Detecting Nucleic Acid 有权
    双功能化学，检测核酸的制备和应用

    公开(公告)号：US20080118405A1

    公开(公告)日：2008-05-22

    申请号：US11875755

    申请日：2007-10-19

    申请人： Sabrina Conoci ,  Salvatore Sortino

    发明人： Sabrina Conoci ,  Salvatore Sortino

    IPC分类号： B01J19/00 ,  C07D211/04

    CPC分类号： C07D213/30

    摘要： A bifunctional compound comprising a molecular unit (I) intercalating between nucleobases (B) of nucleic acids, an active molecular unit (AD) capable of emitting a detectable signal, and optionally a spacer unit, in which the active molecular unit (AD) is selected from amongst chemical entities having a structure such as to interact electronically with the intercalating molecular unit (I) in such a way that, during the reaction of oxidation, the reduction-oxidation potential (EI+/I) of the semicouple I+/I defined by the intercalating molecular unit (I) is lower than the reduction-oxidation potential (EB+/B) of the semicouple B+/B defined by the nucleobases (B), and in such a way that, during the reaction of reduction, the reduction-oxidation potential (EI/I−) of the semicouple I/I− defined by the intercalating molecular unit (I) is higher than the reduction-oxidation potential (EB/B−) of the semicouple B/B− defined by the nucleobases (B). Moreover the use of the compound for detecting nucleic acids, a process for its synthesis, and a system comprising the same are described.

    摘要翻译： 包含嵌入核酸碱基（B）之间的分子单元（I），能够发射可检测信号的活性分子单元（AD）和任选的间隔单元的双功能化合物，其中活性分子单元（AD）为 选自具有如下结构的化学实体，其结构使得与插层分子单元（I）以电子方式相互作用，使得在氧化反应期间，所述半导体I + / I的还原氧化电位（EI + / I）被定义 插层分子单元（I）的含量低于由核碱基（B）定义的半组分B + / B的还原 - 氧化电位（EB + / B），并且在还原反应期间还原 由插入分子单元（I）定义的半配偶I / I的氧化电位（EI / I）高于由核碱基限定的半组分B / B-的还原 - 氧化电位（EB / B-） （B）。 此外，描述了化合物用于检测核酸的用途，其合成方法和包含其的体系。