专利检索 ap:("Sachin MITTAL" OR "Irina KAZAKEVICH" OR "Himanshu BHATTAQCHARJEE" OR "Peter BAKKER" OR "Luke J. SCHENCK" OR "David J. GOLDFARB" OR "Amitava MITRA" OR "Donna CARROLL" OR "Nazia KHAWAJA" OR "MERCK SHARP & DOHME CORP." OR "MERCK SHARP & DOHME B. V.") AND inv:"Luke Schenck" 第 1 页

1.

发明申请
FORMULATION FOR PARENTERAL ADMINISTRATION 审中-公开

公开(公告)号：US20200289406A1

公开(公告)日：2020-09-17

申请号：US16496182

申请日：2018-03-19

申请人： Sachin MITTAL , Irina KAZAKEVICH , Himanshu BHATTAQCHARJEE , Peter BAKKER , Luke J. SCHENCK , David J. GOLDFARB , Amitava MITRA , Donna CARROLL , Nazia KHAWAJA , MERCK SHARP & DOHME CORP. , MERCK SHARP & DOHME B. V.

发明人： Sachin Mittal , Irina Kazakevich , Himanshu Bhattacharjee , Peter Bakker , Luke Schenck , David J. Goldfarb , Amitava Mitra , Donna Carroll , Nazia Khawaja

IPC分类号： A61K9/00 , A61K31/4439 , A61K47/26 , A61K47/22 , A61K47/10 , A61K47/38

摘要： The instant invention provides pharmaceutical formulations for a long acting injectable drug product comprising a suspension of doravirine for parenteral administration via intramuscular or subcutaneous routes. The drug product can be used for the treatment or prophylaxis of infection by HIV or for the treatment, prophylaxis, or delay in the onset of AIDS (acquired immunodeficiency syndrome) or ARC (AIDS related complex).

2.

发明授权
Formulation for parenteral administration 有权

公开(公告)号：US11077050B2

公开(公告)日：2021-08-03

申请号：US16496182

申请日：2018-03-19

申请人： MERCK SHARP & DOHME CORP. , MERCK SHARP & DOHME B. V. , Sachin Mittal , Irina Kazakevich , Himanshu Bhattacharjee , Peter Bakker , Luke Schenck , David J. Goldfarb , Amitava Mitra , Donna Carroll , Nazia Khawaja

发明人： Sachin Mittal , Irina Kazakevich , Himanshu Bhattacharjee , Peter Bakker , Luke Schenck , David J. Goldfarb , Amitava Mitra , Donna Carroll , Nazia Khawaja

IPC分类号： A61K31/4439 , A61K9/00 , A61K47/10 , A61K47/22 , A61K47/26 , A61K47/38 , A61K9/10

摘要： The instant invention provides pharmaceutical formulations for a long acting injectable drug product comprising a suspension of doravirine for parenteral administration via intramuscular or subcutaneous routes. The drug product can be used for the treatment or prophylaxis of infection by HIV or for the treatment, prophylaxis, or delay in the onset of AIDS (acquired immunodeficiency syndrome) or ARC (AIDS related complex).

3.

发明申请
Containment System for Mixing Dry Powders with Solvents During Drug Production or Processing 有权

公开(公告)号：US20220250013A1

公开(公告)日：2022-08-11

申请号：US17618641

申请日：2020-06-15

申请人： Merck Sharp & Dohme Corp.

发明人： John H. Roosa , Alan S. D'Alessandro , Robert O'Connor , Luke Schenck , Timothy Stanoch

IPC分类号： B01F21/10 , B01F35/71 , B01F35/75

摘要： A solids charging containment apparatus and method for mixing a solvent with a dry powder, comprising a dual compartment isolator for safely removing the dry powder from a dry powder container, a mixing vessel, and a negative cascading pressure controller. The dual compartment isolator comprises a staging compartment, a charging compartment and a raw material entry port, which is connected to the staging compartment and configured to isolate the dry powder container from the surrounding atmosphere. The mixing vessel includes a mixing chamber and a solids charging port fluidly connecting the mixing chamber to a containment valve in the charging compartment of the dual compartment isolator. The negative cascading pressure controller generates negative pressure in both the staging compartment and the charging compartment. The containment apparatus and method may be used to produce a slurry or solution mixture of solvent and dry powder during drug processing.