公开(公告)号：US12037327B2

公开(公告)日：2024-07-16

申请号：US17052584

申请日：2019-05-03

申请人： Saint Louis University

发明人： Christopher Kent Arnatt ,  Chelsea DeLeon

IPC分类号： C07D407/04 ,  A61K31/135 ,  A61K31/136 ,  A61K31/137 ,  A61K45/06 ,  C07D213/38 ,  C07D307/52 ,  C07D333/20 ,  G01N33/50 ,  G01N21/64

CPC分类号： C07D407/04 ,  A61K45/06 ,  C07D213/38 ,  C07D307/52 ,  C07D333/20 ,  G01N33/502 ,  G01N21/64

摘要： In one aspect, the present disclosure provides compounds of the formula (I): In other aspects, the present disclosure provides compositions and methods of targeting GPER for the treatment of cancers, such as breast cancers and leukemias, gallstone disease, cardiovascular disease, and for conferring of neuroprotection on a subject. Also disclosed are high throughput assays for identifying antagonists of GPER.

公开(公告)号：US11634378B2

公开(公告)日：2023-04-25

申请号：US16498571

申请日：2018-03-29

申请人： Saint Louis University

发明人： Christopher Kent Arnatt ,  Chelsea DeLeon

IPC分类号： C07C211/48 ,  C07C211/55 ,  C07C211/54 ,  C07C211/43 ,  C07C217/58 ,  A61P1/16 ,  A61K45/06 ,  A61K31/137

摘要： The present disclosure provides compositions and method targeting GPER for the treatment of cancers, such as breast cancers and leukemias, gallstone disease, and for conferring of neuroprotection on a subject. Also disclosed are high throughput assays for identifying antagonists of GPER.