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    Selective high-affinity polydentate ligands and methods of making such
    1.
    发明授权
    Selective high-affinity polydentate ligands and methods of making such 有权
    选择性高亲和力多齿配体及其制备方法

    公开(公告)号：US08536133B2

    公开(公告)日：2013-09-17

    申请号：US12642684

    申请日：2009-12-18

    申请人： Sally DeNardo ,  Gerald DeNardo ,  Rodney Balhorn

    发明人： Sally DeNardo ,  Gerald DeNardo ,  Rodney Balhorn

    IPC分类号： A61K38/00 ,  A61K31/33

    CPC分类号： G01N33/6803 ,  G01N33/574

    摘要： This invention provides polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each binds different regions on the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

    摘要翻译： 本发明提供多齿选择性高亲和力配体（SHAL），其可以以与使用抗体类似的方式用于多种应用。 SHAL通常包含多个配体，其各自结合靶分子上的不同区域。 配体直接或通过接头连接，从而形成通常以高选择性和亲合力结合目标分子的多齿部分。

    Selective high affinity polydentate ligands and methods of making such
    2.
    发明申请
    Selective high affinity polydentate ligands and methods of making such 有权
    选择性高亲和力多齿配体及其制备方法

    公开(公告)号：US20060084115A1

    公开(公告)日：2006-04-20

    申请号：US11055181

    申请日：2005-02-09

    申请人： Sally DeNardo ,  Gerald DeNardo ,  Rodney Balhorn

    发明人： Sally DeNardo ,  Gerald DeNardo ,  Rodney Balhorn

    IPC分类号： C40B40/10 ,  C40B50/14

    CPC分类号： G01N33/6803 ,  G01N33/574

    摘要： This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

    摘要翻译： 本发明提供了新颖的多齿选择性高亲和力配体（SHAL），其可以以与使用抗体类似的方式用于多种应用。 SHAL通常包含多个配体，其各自结合不同区域的靶分子。 配体直接或通过接头连接，从而形成通常以高选择性和亲合力结合目标分子的多齿部分。

    Selective high affinity polydentate ligands and methods of making such
    4.
    发明授权
    Selective high affinity polydentate ligands and methods of making such 有权
    选择性高亲和力多齿配体及其制备方法

    公开(公告)号：US07662785B2

    公开(公告)日：2010-02-16

    申请号：US11055181

    申请日：2005-02-09

    申请人： Sally DeNardo ,  Gerald DeNardo ,  Rodney Balhorn

    发明人： Sally DeNardo ,  Gerald DeNardo ,  Rodney Balhorn

    IPC分类号： A61K38/08

    CPC分类号： G01N33/6803 ,  G01N33/574

    摘要： This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

    摘要翻译： 本发明提供了新颖的多齿选择性高亲和力配体（SHAL），其可以以与使用抗体类似的方式用于多种应用。 SHAL通常包含多个配体，其各自结合不同区域的靶分子。 配体直接或通过接头连接，从而形成通常以高选择性和亲合力结合目标分子的多齿部分。

    On-demand cleavable linkers for radioconjugates for cancer imaging and therapy
    5.
    发明申请
    On-demand cleavable linkers for radioconjugates for cancer imaging and therapy 审中-公开
    用于癌症成像和治疗的放射性缀合物的按需可切割接头

    公开(公告)号：US20050255042A1

    公开(公告)日：2005-11-17

    申请号：US10997759

    申请日：2004-11-23

    申请人： Kit Lam ,  Pappanaicken Kumaresan ,  Sally DeNardo ,  Gerald DeNardo

    发明人： Kit Lam ,  Pappanaicken Kumaresan ,  Sally DeNardo ,  Gerald DeNardo

    IPC分类号： A61K20060101 ,  A61K51/00 ,  A61K51/10

    CPC分类号： A61K51/1093

    摘要： The present invention provides compositions comprising a biological agent, a targeting moiety, and a peptide linker attaching the biological agent to the targeting moiety, wherein the peptide linker is selectively cleaved by a protease. Efficient methods are provided for administering the compositions of the present invention for treating cancer or imaging a tumor, organ, or tissue in a subject. Kits are also provided for administering the compositions of the present invention for radiotherapy or radioimaging.

    摘要翻译： 本发明提供了包含生物试剂，靶向部分和将生物试剂连接到靶向部分的肽接头的组合物，其中肽接头被蛋白酶选择性地切割。 提供了有效的方法来施用本发明的治疗癌症或成像受试者的肿瘤，器官或组织的组合物。 还提供了用于将本发明的组合物用于放射治疗或放射成像的试剂盒。