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公开(公告)号：US06989144B1
公开(公告)日：2006-01-24
申请号：US09610118
申请日：2000-06-30
申请人： Samatha J. Busfield , Jean-Luc Villeval , Martine Jandrot-Perrus , William Vainchencker , Davinder Singh Gill , Ming Diana Qian , Gillian Kingsbury
发明人： Samatha J. Busfield , Jean-Luc Villeval , Martine Jandrot-Perrus , William Vainchencker , Davinder Singh Gill , Ming Diana Qian , Gillian Kingsbury
IPC分类号： A61K39/395 , C07K16/28 , C12P21/08
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K16/2803 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein V1, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the exposure vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码糖蛋白V1的分离的核酸分子和多肽分子，血小板膜糖蛋白涉及血小板 - 胶原相互作用。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，其中引入了暴露载体的宿主细胞，以及其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US20060216291A1
公开(公告)日：2006-09-28
申请号：US11447460
申请日：2006-06-06
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K16/2803 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
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公开(公告)号：US20100261200A1
公开(公告)日：2010-10-14
申请号：US12690710
申请日：2010-01-20
IPC分类号： G01N33/53 , G01N33/566 , C12N5/02
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K16/2803 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子和编码糖蛋白VI的多肽分子，其涉及血小板 - 胶原相互作用的血小板膜糖蛋白。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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4.发明授权公开(公告)号：US06245527B1
公开(公告)日：2001-06-12
申请号：US09345468
申请日：1999-06-30
IPC分类号： C12N1512
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K2317/565 , C07K2317/622 , C07K2319/00
摘要： The invention provides isolated TANGO 268 nucleic acid molecules and polypeptide molecules. TANGO 268 encodes a polypeptide that represents glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的TANGO 268核酸分子和多肽分子。 TANGO 268编码代表糖蛋白VI的多肽，血小板膜糖蛋白涉及血小板 - 胶原相互作用。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US07291714B1
公开(公告)日：2007-11-06
申请号：US09503387
申请日：2000-02-14
IPC分类号： C07K16/28 , C12P21/08 , G01N33/53 , G01N33/534 , G01N33/535
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K16/2803 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子和编码糖蛋白VI的多肽分子，其涉及血小板 - 胶原相互作用的血小板膜糖蛋白。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US08137923B2
公开(公告)日：2012-03-20
申请号：US12690710
申请日：2010-01-20
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K16/2803 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子和编码糖蛋白VI的多肽分子，其涉及血小板 - 胶原相互作用的血小板膜糖蛋白。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US06383779B1
公开(公告)日：2002-05-07
申请号：US09414453
申请日：1999-10-07
IPC分类号： C12P2106
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K2317/565 , C07K2317/622 , C07K2319/00
摘要： The invention provides isolated TANGO 268 nucleic acid molecules and polypeptide molecules. TANGO 268 encodes a polypeptide that represents glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的TANGO 268核酸分子和多肽分子。 TANGO 268编码代表糖蛋白VI的多肽，涉及血小板 - 胶原相互作用的血小板膜糖蛋白。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，表达载体具有的宿主细胞 和其中本发明的核酸分子被引入或破坏的非人转基因动物。 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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