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    Anti-glycoprotein VI scFv fragment for treatment of thrombosis
    1.
    发明授权
    Anti-glycoprotein VI scFv fragment for treatment of thrombosis 有权
    抗糖蛋白VI scFv片段用于治疗血栓形成

    公开(公告)号：US09045538B2

    公开(公告)日：2015-06-02

    申请号：US12312080

    申请日：2007-10-26

    申请人： Martine Jandrot-Perrus ,  Philippe Billiald ,  Julien Muzard

    发明人： Martine Jandrot-Perrus ,  Philippe Billiald ,  Julien Muzard

    IPC分类号： C12P21/08 ,  A61K39/00 ,  C12N5/07 ,  C12N5/16 ,  C07H21/04 ,  C07K16/28 ,  C07H21/00

    CPC分类号： C07K16/28 ,  A61K39/00 ,  A61K2039/505 ,  C07H21/00 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/622

    摘要： The present invention relates to a single chain variable fragment (scFv 9O12.2) directed against human glycoprotein VI, constituted of the VH and VL domains of 9 O12.2.2 monoclonal antibody linked via a (Gly4Ser)3 peptide and followed by a “c-myc” flag, represented by SEQ ID NO:1. The invention also concerns functional variants of said scFv 9O12.2 fragment with identical heavy and light chains complementary determining regions 1, 2 and 3, and preferably humanized functional variants such as the humanized scFv fragments represented by SEQ ID NO:28 or SEQ ID NO:47. The invention also relates to nucleic acids encoding such a scFv fragment, expression vectors and host cells to produce such a scFv fragment, as well as therapeutic uses of such a scFv fragment.

    摘要翻译： 本发明涉及针对人类糖蛋白VI的单链可变片段（scF99012），其由通过（Gly4Ser）3肽连接的9 O12.2.2单克隆抗体的VH和VL结构域构成，然后是“c -myc“标记，由SEQ ID NO：1表示。 本发明还涉及具有相同重链和轻链互补决定区1,2和3的所述scF99012片段的功能变体，优选人源化功能变体如SEQ ID NO：28或SEQ ID NO所示的人源化scFv片段 ：47。 本发明还涉及编码这种scFv片段，表达载体和宿主细胞以产生这种scFv片段的核酸以及这种scFv片段的治疗用途。

    ANTI-GLYCOPROTEIN VI SCFV FRAGMENT FOR TREATMENT OF THROMBOSIS
    2.
    发明申请
    ANTI-GLYCOPROTEIN VI SCFV FRAGMENT FOR TREATMENT OF THROMBOSIS 有权
    抗葡萄球蛋白VI SCFV片段治疗血栓形成

    公开(公告)号：US20130189259A1

    公开(公告)日：2013-07-25

    申请号：US13724134

    申请日：2012-12-21

    申请人： Martine Jandrot-Perrus ,  Philippe Billiald ,  Julien Muzard

    发明人： Martine Jandrot-Perrus ,  Philippe Billiald ,  Julien Muzard

    IPC分类号： C07K16/28

    CPC分类号： C07K16/28 ,  A61K39/00 ,  A61K2039/505 ,  C07H21/00 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/622

    摘要： The present invention relates to a single chain variable fragment (scFv 9O12.2) directed against human glycoprotein VI, constituted of the VH and VL domains of 9 O12.2.2 monoclonal antibody linked via a (Gly4Ser)3 peptide and followed by a “c-myc” flag, represented by SEQ ID NO:1. The invention also concerns functional variants of said scFv 9O12.2 fragment with identical heavy and light chains complementary determining regions 1, 2 and 3, and preferably humanized functional variants such as the humanized scFv fragments represented by SEQ ID NO:28 or SEQ ID NO:47. The invention also relates to nucleic acids encoding such a scFv fragment, expression vectors and host cells to produce such a scFv fragment, as well as therapeutic uses of such a scFv fragment.

    摘要翻译： 本发明涉及针对人类糖蛋白VI的单链可变片段（scF99012），其由通过（Gly4Ser）3肽连接的9 O12.2.2单克隆抗体的VH和VL结构域构成，然后是“c -myc“标记，由SEQ ID NO：1表示。 本发明还涉及具有相同重链和轻链互补决定区1,2和3的所述scF99012片段的功能变体，优选人源化功能变体如SEQ ID NO：28或SEQ ID NO所示的人源化scFv片段 ：47。 本发明还涉及编码这种scFv片段，表达载体和宿主细胞以产生这种scFv片段的核酸以及这种scFv片段的治疗用途。

    ANTI-GLYCOPTROTEIN VI SCFV FRAGMENT FOR TREATMENT OF THROMBOSIS
    3.
    发明申请
    ANTI-GLYCOPTROTEIN VI SCFV FRAGMENT FOR TREATMENT OF THROMBOSIS 有权
    用于治疗血栓形成的抗GLYCOPTROTEIN VI SCFV片段

    公开(公告)号：US20110182899A1

    公开(公告)日：2011-07-28

    申请号：US12312080

    申请日：2007-10-26

    申请人： Martine Jandrot-Perrus ,  Philippe Billiald ,  Julien Muzard

    发明人： Martine Jandrot-Perrus ,  Philippe Billiald ,  Julien Muzard

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C07H21/04 ,  C12N15/85 ,  C12N5/10 ,  C12P21/02 ,  A61P7/02 ,  A61P9/00 ,  C12N1/00 ,  A61P9/10

    CPC分类号： C07K16/28 ,  A61K39/00 ,  A61K2039/505 ,  C07H21/00 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/622

    摘要： The present invention relates to a single chain variable fragment (scFv 9O12.2) directed against human glycoprotein VI, constituted of the VH and VL domains of 9 O12.2.2 monoclonal antibody linked via a (Gly4Ser)3 peptide and followed by a “c-myc” flag, represented by SEQ ID NO:1. The invention also concerns functional variants of said scFv 9O12.2 fragment with identical heavy and light chains complementary determining regions 1, 2 and 3, and preferably humanized functional variants such as the humanized scFv fragments represented by SEQ ID NO:28 or SEQ ID NO:47. The invention also relates to nucleic acids encoding such a scFv fragment, expression vectors and host cells to produce such a scFv fragment, as well as therapeutic uses of such a scFv fragment.

    摘要翻译： 本发明涉及针对人类糖蛋白VI的单链可变片段（scF99012），其由通过（Gly4Ser）3肽连接的9 O12.2.2单克隆抗体的VH和VL结构域构成，然后是“c -myc“标记，由SEQ ID NO：1表示。 本发明还涉及具有相同重链和轻链互补决定区1,2和3的所述scF99012片段的功能变体，优选人源化功能变体如SEQ ID NO：28或SEQ ID NO所示的人源化scFv片段 ：47。 本发明还涉及编码这种scFv片段，表达载体和宿主细胞以产生这种scFv片段的核酸以及这种scFv片段的治疗用途。

    Glycoprotein VI and Uses Thereof
    9.
    发明申请
    Glycoprotein VI and Uses Thereof 有权
    糖蛋白VI及其用途

    公开(公告)号：US20100261200A1

    公开(公告)日：2010-10-14

    申请号：US12690710

    申请日：2010-01-20

    申请人： Samantha J. Busfield ,  Jean-Luc Villeval ,  Martine Jandrot-Perrus ,  William Vainchencker

    发明人： Samantha J. Busfield ,  Jean-Luc Villeval ,  Martine Jandrot-Perrus ,  William Vainchencker

    IPC分类号： G01N33/53 ,  G01N33/566 ,  C12N5/02

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K16/28 ,  C07K16/2803 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子和编码糖蛋白VI的多肽分子，其涉及血小板 - 胶原相互作用的血小板膜糖蛋白。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。