公开(公告)号：US09879081B2

公开(公告)日：2018-01-30

申请号：US14315068

申请日：2014-06-25

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hye Young Suh ,  Jae Il Lee ,  Su-Jeong Hwang

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/32 ,  C07K16/46 ,  C07K16/22

CPC classification number: C07K16/22 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/73

Abstract: A protein complex comprising a first polypeptide comprising a first antigen-binding region; a second polypeptide comprising a second antigen-binding region; anda linker connecting the first polypeptide and the second polypeptide, wherein the first antigen-binding region is a single stranded polypeptide comprising a first light chain antigen-binding region and a first heavy chain antigen-binding region, the second antigen-binding region is a single stranded polypeptide comprising a second light chain antigen-binding region and a second heavy chain antigen-binding region, and the linker connects the C-terminal of the first polypeptide and the N-terminal of the second polypeptide, and comprises a tag including a cleavable amino acid sequence at one terminal or both terminals of the linker; as well as a bispecific antibody derived from the protein complex, and related compositions and methods.

公开(公告)号：US20140378664A1

公开(公告)日：2014-12-25

申请号：US14315068

申请日：2014-06-25

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hye young SUH ,  Jae II Lee ,  Su-Jeong Hwang

IPC: C07K16/18

CPC classification number: C07K16/22 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/73

Abstract: A protein complex comprising a first polypeptide comprising a first antigen-binding region; a second polypeptide comprising a second antigen-binding region; anda linker connecting the first polypeptide and the second polypeptide, wherein the first antigen-binding region is a single stranded polypeptide comprising a first light chain antigen-binding region and a first heavy chain antigen-binding region, the second antigen-binding region is a single stranded polypeptide comprising a second light chain antigen-binding region and a second heavy chain antigen-binding region, and the linker connects the C-terminal of the first polypeptide and the N-terminal of the second polypeptide, and comprises a tag including a cleavable amino acid sequence at one terminal or both terminals of the linker; as well as a bispecific antibody derived from the protein complex, and related compositions and methods.

Abstract translation: 一种包含第一多肽的蛋白质复合物，所述第一多肽包含第一抗原结合区域; 包含第二抗原结合区的第二多肽; 和连接第一多肽和第二多肽的接头，其中第一抗原结合区是包含第一轻链抗原结合区和第一重链抗原结合区的单链多肽，第二抗原结合区是 包含第二轻链抗原结合区和第二重链抗原结合区的单链多肽，所述连接体连接第一多肽的C-末端和第二多肽的N-末端，并且包含标签，包括 连接子的一个末端或两个末端的可切割氨基酸序列; 以及衍生自蛋白质复合物的双特异性抗体，以及相关的组合物和方法。