公开(公告)号：US20140294837A1

公开(公告)日：2014-10-02

申请号：US14228521

申请日：2014-03-28

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Yun Jeong SONG ,  Ho Yeong SONG ,  Seung Hyun LEE ,  Kyung Ah KIM ,  Yun Ju JEONG

IPC: C07K16/32 ,  C07K16/22

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K14/71 ,  C07K2317/10 ,  C07K2317/24 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: There are provided a fusion protein formed by coupling of anti-c-Met antibody and VEGF-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-Met and VEGF at the same time, with improved anticancer and anti-angiogenesis effects, comprising coupling an anti-c-Met antibody with a VEGF-binding fragment.

Abstract translation: 提供了通过偶联抗c-Met抗体和VEGF结合片段，包含融合蛋白的双特异性抗体，编码融合蛋白的多核苷酸，包含多核苷酸的转化体，包含双特异性抗体的药物组合物形成的融合蛋白 作为活性成分，以及同时制备靶向c-Met和VEGF的双特异性抗体的方法，具有改善的抗癌和抗血管生成作用，包括将抗c-Met抗体与VEGF结合偶联 分段。

公开(公告)号：US20150192588A1

公开(公告)日：2015-07-09

申请号：US14591787

申请日：2015-01-07

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Soo Yeon JUNG ,  Seon Hui SHIM ,  Yun Jeong SONG ,  Hyeon-seok YOO

IPC: G01N33/574 ,  C07K16/40

CPC classification number: G01N33/57488 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57446 ,  G01N2333/495 ,  G01N2333/5421 ,  G01N2333/99 ,  G01N2800/52

Abstract: A biomarker for predicting and/or monitoring the efficacy of a c-Met inhibitor; a composition for predicting and/or monitoring the efficacy of a c-Met inhibitor, comprising a material detecting the biomarker; a composition for selecting a subject suitable for the application of a c-Met inhibitor, comprising a material detecting the biomarker; a method for predicting and/or monitoring the efficacy of a c-Met inhibitor using the biomarker; a method for selecting a subject suitable for the application of a c-Met inhibitor using the biomarker; and a method for preventing and/or treating cancer comprising administering a c-Met inhibitor to the selected subject.

Abstract translation: 用于预测和/或监测c-Met抑制剂功效的生物标志物; 用于预测和/或监测c-Met抑制剂的功效的组合物，其包含检测生物标志物的材料; 用于选择适合于施用c-Met抑制剂的受试者的组合物，其包含检测所述生物标志物的材料; 用于使用该生物标志物预测和/或监测c-Met抑制剂的功效的方法; 用于选择适合于使用所述生物标志物应用c-Met抑制剂的受试者的方法; 以及用于预防和/或治疗癌症的方法，包括向所选择的受试者施用c-Met抑制剂。

公开(公告)号：US20210269533A1

公开(公告)日：2021-09-02

申请号：US17193804

申请日：2021-03-05

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun LEE ,  Geun Woong KIM ,  Kyung Ah KIM ,  Hye Won PARK ,  Ho Yeong SONG ,  Young Mi OH ,  Saet Byoul LEE ,  Ji Min LEE ,  Kwang Ho CHEONG ,  Yun Ju JEONG ,  Mi Young CHO ,  Jae Hyun CHOI ,  Yun Jeong SONG ,  Yoon Aa CHOI

IPC: C07K16/28

Abstract: An anti-c-Met antibody or antibody fragment and pharmaceutical composition comprising same, as well as a method for preventing and treating cancer by administering the antibody to a subject are provided.

公开(公告)号：US20140086926A1

公开(公告)日：2014-03-27

申请号：US14025403

申请日：2013-09-12

Applicant: Samsung Electronics Co., Ltd.

Inventor： Yun Ju JEONG ,  Kyung Ah KIM ,  Yun Jeong SONG ,  Ji Min LEE ,  Hyo Seon LEE ,  Jae Hyun CHOI ,  Saet Byoul LEE

IPC: A61K39/395 ,  A61K45/06

CPC classification number: A61K39/3955 ,  A61K45/06 ,  C07K16/2863 ,  C07K2317/24

Abstract: Provided is a method of combination therapy for prevention or treatment of c-Met-induced or angiogenesis factor-induced diseases including co-administering an angiogenesis inhibitor and an anti-c-Met antibody or an antigen-binding fragment thereof to a patient.

Abstract translation: 提供了用于预防或治疗c-Met诱导或血管生成因子诱导的疾病的组合疗法的方法，包括向患者共同给予血管生成抑制剂和抗c-Met抗体或其抗原结合片段。