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53 条记录 (耗时 0.043 秒)

    Receptor-avid exogenous optical contrast and therapeutic agents
    1.
    发明授权
    Receptor-avid exogenous optical contrast and therapeutic agents 有权
    受体 - 狂热的外源性光学对比和治疗剂

    公开(公告)号：US07790144B2

    公开(公告)日：2010-09-07

    申请号：US10800531

    申请日：2004-03-15

    申请人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph Bugaj ,  Muthunadar P. Periasamy

    发明人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph Bugaj ,  Muthunadar P. Periasamy

    IPC分类号： A61B5/00 ,  A61B10/00

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056 ,  C07D209/12 ,  C07D405/14 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/08 ,  C09B23/086

    摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologes. The compounds are be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1,300 nm, the exact range being dependent upon the particular dye. The use of a biocompatible organic solvent such as dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 公开了可用于诊断成像和治疗的花青染料生物缀合物。 缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。 化合物与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。 各种染料在350至1,300nm的范围内是有用的，精确的范围取决于特定的染料。 使用生物相容性有机溶剂如二甲基亚砜有助于维持化合物的荧光。 本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗。

    Tunable indocyanine dyes for biomedical applications
    10.
    发明授权
    Tunable indocyanine dyes for biomedical applications 失效
    可调式吲哚菁染料用于生物医学应用

    公开(公告)号：US06180087B2

    公开(公告)日：2001-01-30

    申请号：US09484320

    申请日：2000-01-18

    申请人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    发明人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    IPC分类号： A61B1000

    CPC分类号： A61K41/0033

    摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel indocyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 通过使用高吸收性染料作为造影剂可以提高光学模态的灵敏度和特异性。 公开了在电磁光谱的近红外区域吸收和发射光的新型吲哚菁染料。 这些染料可用于各种疾病状态的成像，诊断和治疗。 特别地，本发明的分子可用于光学诊断成像和治疗，在用于检测肿瘤和其他异常的内窥镜应用中，用于局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗 。